{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:00:40Z","timestamp":1767164440721,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current study aimed to evaluate the significance of clinicopathological factors, particularly the immunohistochemistry of programed cell death ligand\u20101 (PD\u2010L1), in eight cases each of pulmonary sarcomatoid carcinoma (PSC) and malignant pleural mesothelioma (MPM) at our hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2004 to December 2020, a total of 16 consecutive patients (eight with PSC and eight with MPM diagnosed via surgical resection or biopsy) were included in this study. After retrospectively reviewing the patient characteristics, the associations between PD\u2010L1 status and age, sex, stage, histological type, and prognosis were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PD\u2010L1\u2010positive staining was observed in four (50%) PSC cases and one (12.5%) MPM case. Among the four PD\u2010L1\u2010positive PSC cases, two showed high PD\u2010L1 expression in the vimentin\u2010positive sarcomatoid compartment. Moreover, among those with PSC, two survived for about 10\u2009years, whereas the others died within 5\u2009years. No clear correlation was found between PD\u2010L1 expression and prognosis. Among the patients with MPM, four survived for more than 2\u2009years, with the longest being 9\u2009years. Among MPM cases who received nivolumab, one patient with positive PD\u2010L1 staining in the sarcomatoid survived, whereas the other with negative PD\u2010L1 staining did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study showed that sarcomatoid carcinoma had a higher PD\u2010L1 expression compared to non\u2010small\u2010cell lung cancer and that both PSC and MPM tended to exhibit PD\u2010L1 positivity in the sarcomatoid compartment. Moreover, while immune checkpoint inhibitors may somewhat prolong the prognosis of both tumors, further studies with a larger cohort are necessary to confirm our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.14177","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T15:48:23Z","timestamp":1634744903000},"page":"3169-3176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thoracic mesenchymal malignant tumors and programed cell death ligand\u20101 status: Clinicopathologic and prognostic analysis of eight pulmonary sarcomatoid carcinomas and eight malignant mesotheliomas"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-4988","authenticated-orcid":false,"given":"Kanji","family":"Otsubo","sequence":"first","affiliation":[{"name":"Departments of Chest Surgery St. Marianna University School of Medicine  Kawasaki 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