{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:27:30Z","timestamp":1767713250646,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 66\u2010year\u2010old man with squamous cell carcinoma had been receiving chemoradiation therapy after stereotactic radiotherapy for brain metastases. Atezolizumab was initiated as second\u2010line therapy, after which the patient became progression\u2010 and recurrence\u2010free. Four days after his second dose of tozinameran (BNT162b2, Pfizer\u2010BioNTech), the patient developed persistent hemoptysis. The patient had no thrombocytopenia or coagulation abnormalities. Bronchoscopy revealed active bleeding from the left lingual tracheal branch. The patient was intubated and admitted to the intensive care unit because of increased bleeding. Subsequently, left bronchial artery embolization was performed using a Serescue. Hemostasis was achieved after the procedure, and the patient was discharged 7\u2009days after the onset of hemoptysis. Vaccination against coronavirus disease has been reported to be associated with thrombosis and cerebral hemorrhage, and the hemoptysis in this case was suspected to be induced by vaccination. In summary, the benefits of vaccination exceeded the risks of adverse events in a patient with cancer. However, in conditions such as after chemoradiation, especially in patients with radiation pneumonitis wherein the vasculature is vulnerable, patients should be carefully monitored for hemorrhagic events after vaccination.<\/jats:p>","DOI":"10.1111\/1759-7714.14179","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T01:53:47Z","timestamp":1633658027000},"page":"3072-3075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung squamous cell carcinoma with hemoptysis after vaccination with tozinameran (<scp>BNT162b2<\/scp>, <scp>Pfizer\u2010BioNTech<\/scp>)"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-5878","authenticated-orcid":false,"given":"Toshiyuki","family":"Sumi","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"},{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Nagahisa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"},{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"},{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Sekikawa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"},{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hakodate Goryoukaku Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"EMA\u2014 Medicines Agency. COVID\u201019 vaccine safety update for Vaxzevria (previously COVID\u201019 vaccine Astra Zeneca); 2021. Available from:https:\/\/www.ema.europa.eu\/en\/documents\/covid\u201019\u2010vaccine\u2010safety\u2010update\/covid\u201019\u2010vaccine\u2010safety\u2010update\u2010vaxzevria\u2010previously\u2010covid\u201019\u2010vaccine\u2010astrazeneca\u20108\u2010september\u20102021_en.pdf. Accessed August 17 2021."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102685"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40545-020-00279-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2004.n.021"},{"key":"e_1_2_6_7_1","first-page":"644","article-title":"Bronchial arterial hemodynamics after thoracic irradiation therapy in lung cancer patients","volume":"32","author":"Nambu Y","year":"1994","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10907"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1470"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105941"},{"key":"e_1_2_6_12_1","unstructured":"COVID\u201019 Vaccine and Patients with CancerAvailable from:https:\/\/www.asco.org\/asco\u2010coronavirus\u2010resources\/covid\u201019\u2010patient\u2010care\u2010information\/covid\u201019\u2010vaccine\u2010patients\u2010cancer2021. Accessed August 17 2021."},{"key":"e_1_2_6_13_1","unstructured":"ESMO.Statements for vaccination against COVID\u201019. Patients with cancer. Switzerland: European Society for Medical Oncology (ESMO); 2021. Available from:https:\/\/www.esmo.org\/covid-19-and-cancer\/covid-19-vaccination. Accessed August 17 2021."},{"key":"e_1_2_6_14_1","unstructured":"MSK COVID\u201019 Vaccine Interim Guidelines for Cancer Patients; 2021. Available from:https:\/\/www.asco.org\/sites\/new-www.asco.org\/files\/content-files\/2021-MSK_COVID19_VACCINE_GUIDELINES_final_V.2.pdf. Accessed August 17 2021."}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:27:53Z","timestamp":1693200473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":13,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/1759-7714.14179"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14179","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"assertion":[{"value":"2021-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}