{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:44:10Z","timestamp":1762508650542,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to assess the efficacy and side\u2010effects of intrapleural treatment in non\u2010small cell lung cancer (NSCLC) patients with malignant pleural effusions (MPEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of NSCLC patients with MPEs diagnosed in four Chinese hospitals from October 2014 to December 2019 were searched. The Kaplan\u2013Meier method is used to calculate median overall survival (MOS) and subgroup analyses are done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 285 patients were evaluated; 81.1% of patients received intrapleural treatment, and no patients received talc pleurodesis. MOS of the whole cohort was 21\u2009months. Patients were divided into three groups: erythromycin group (EG; intrapleural treatment with drugs and erythromycin); intrathoracic treatment group (ITG; intrapleural treatment with drugs); control group (CG; no drug treatment in the pleural cavity). The MOS of patients in the EG, ITG and CG was 20, 22, and 19\u2009months, respectively. Among patients who received only chemotherapy as systemic therapy, the MOS of intrathoracic administration group (IAG; i.e., EG and ITG) was longer than that of CG (12 vs. 6\u2009months; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034), and the MOS of patients with a ratio of carcinoembryonic antigen in pleural effusion (PE\u2010CEA): CEA in blood (B\u2010CEA) \u22641 is worse than that of patients with a ratio &gt;1 (4 vs. 12\u2009months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and that of CG (4 vs. 6\u2009months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.442).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intrapleural treatment can prolong the survival of NSCLC patients with MPE who do not receive targeted treatment or who only receive chemotherapy. The PE\u2010CEA: B\u2010CEA ratio can be used to predict the efficacy if intrapleural treatment is indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14224","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T12:17:04Z","timestamp":1636201024000},"page":"3416-3425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrapleural treatment in patients with non\u2010small cell lung cancer with malignant pleural effusions in the real world"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-2288","authenticated-orcid":false,"given":"Pengfei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine Shandong University  Jinan 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