{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:53:41Z","timestamp":1777100021349,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH027"],"award-info":[{"award-number":["ZR2020QH027"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>NCCN guidelines recommend a dose of 100\u2009\u03bcg\/kg or a fixed dose of 6\u00a0mg pegylated recombinant human granulocyte colony\u2010stimulating factor (PEG rhG\u2010CSF) for chemotherapy\u2010induced neutropenia. However, a single dose of 60\u2009\u03bcg\/kg or 100\u2009\u03bcg\/kg produced a similar neutrophil response among patients with chemotherapy\u2010induced neutropenia (CIN). Thus, this prospective randomized study was designed to investigate the efficacy of 3\u00a0mg PEG rhG\u2010CSF in preventing acute lower respiratory tract infection (ALRTI) after chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with stage IIIB\/IVA lung cancer who underwent chemotherapy were randomly divided into a (i) control group, and (ii) treatment group subject to 3\u00a0mg PEG rhG\u2010CSF after chemotherapy. Patients in the control group were administered rhG\u2010CSF (5\u00a0\u03bcg\/kg) when decreased absolute neutrophil count (ANC) reached grade 3 of adverse events. The primary outcome was incidence of ALRTI, and the secondary outcomes included ANC, febrile neutropenia (FN), incidence of delayed chemotherapy, infection\u2010related medical expenses and adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group, there was a significant decrease in the incidence of ALRTI (9.6% vs. 24.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), FN (1.7% vs. 7.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and neutropenia (8.3% vs. 23.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) in the PEG\u2010rhG\u2010CSF group. The incidence of ALRTI was significantly correlated with the grade of CTCAE on ANC. The main adverse reactions of PEG\u2010rhG\u2010CSF were pain and fatigue, among which three cases showed pain of \u2265 grade 3. The cost of infection\u2010associated medical expenditure in the treatment group was greatly reduced compared with the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ALRTI could well be prevented after prophylactic application of PEG\u2010rhG\u2010CSF (3\u00a0mg), and was related to the reduced neutropenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14233","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:43:32Z","timestamp":1637214212000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of 3 mg pegylated recombinant human granulocyte colony\u2010stimulating factor as support to chemotherapy for lung cancer"],"prefix":"10.1111","volume":"13","author":[{"given":"Xiang","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan China"},{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-2288","authenticated-orcid":false,"given":"Pengfei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-3708","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Qilu Hospital of Shandong University  Jinan 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