{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:29:26Z","timestamp":1787786966950,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thymoma is a type of rare mediastinal tumor whose clinical characteristics and indicators of prognosis are poorly understood. This single\u2010institution retrospective study aimed to assess the predictive value of tumor, node, metastasis (TNM) staging incorporating tumor size in predicting the risk of thymoma recurrence after resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four binary logistic regression models were developed. Models I and II included median tumor size and TNM stage, respectively. Model III included the above two variables. Model IV was model III containing these two variables and their interaction terms. All models were adjusted for WHO histological type, operational time, and adjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 276 patients with a median age of 51.0, including 21 patients with thymoma recurrence, were included in this study. Models II or III showed a lower \u20102LogL and higher AUC (0.735 and 0.738 vs. 0.576) with significantly better discrimination than model I, and model III and model II shared similar discrimination. In model III, TNM stage was positively correlated with thymoma recurrence. The recurrence risk of patients with TNM stage IV was significantly higher than those with TNM stage I (OR of 11.03, <jats:italic>p<\/jats:italic>\u00a0=\u20090.022). No significant correlation between the tumor size and recurrence risk <jats:italic>(p<\/jats:italic>\u00a0=\u20090.779) and no interaction was found between medium tumor size and TNM stage in model IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that the prediction contribution of the TNM stage combined with tumor size is similar to the TNM stage alone for tumor recurrence in patients with thymoma after surgical resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14255","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T22:35:24Z","timestamp":1640039724000},"page":"346-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does size affect the prognosis of resectable thymoma beyond the eighth edition <scp>TNM<\/scp>?"],"prefix":"10.1111","volume":"13","author":[{"given":"Yen\u2010Chiang","family":"Tseng","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Institute of Clinical Medicine, National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Thoracic Surgery, Department of Surgery Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Shui","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine, National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Public Health, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Han","family":"Tseng","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Medical University \u2013 Shuang Ho Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wen","family":"Shu","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical Sciences, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Biomedical Science and Environmental Biology Kaohsiung 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