{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:15:55Z","timestamp":1779124555709,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to investigate the characteristics and pretreatment risk factors for postoperative pulmonary complications (PPCs) after neoadjuvant concurrent chemoradiotherapy (CRTx) in patients with non\u2010small cell lung cancer (NSCLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data of 122 patients who underwent curative resection after neoadjuvant CRTx for NSCLC between 2007 and December 2019. Clinical data, including pulmonary function and body mass index (BMI) at the time of concurrent CRTx initiation, were analyzed. We performed logistic regression analyses to identify the risk factors for PPCs and built a nomogram with significant factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 122 patients included (mean age, 60.1\u2009\u00b1\u20099.7\u2009years; 69.7% male), 27 experienced PPCs (severity grade\u2009\u2265\u20092). The most common PPCs were pneumonia (<jats:italic>n<\/jats:italic>\u00a0=\u00a017). Patients with PPCs had a significantly longer hospital stay (median 6.0 vs. 17\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a higher in\u2010hospital mortality rate (1.1% vs. 29.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In multivariable analysis, lower BMI (odds ratio [OR] 0.796, 95% confidence interval [CI] 0.628\u20130.987, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), no comorbidity (OR 0.220, 95% CI: 0.059\u20130.819, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048), smoking history (OR 4.362, 95% CI: 1.210\u201315.720, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024), and %predicted DLCO &lt;60% (OR 3.727, 95% CI: 1.319\u201310.530, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013) were independent risk factors for PPCs. The predictive accuracy of the nomogram built with factors was excellent (concordance index: 0.756).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nomogram constructed with factors identified in multivariable analysis could serve as a reliable tool for evaluating the risk of PPCs in the patients who underwent neoadjuvant CRTx for NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14263","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T19:29:10Z","timestamp":1639510150000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-2215","authenticated-orcid":false,"given":"Ha Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Sik","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Gu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2360"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.19080\/CTOIJ.2021.17.555973"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.04.24"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.02.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.04.073"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.03.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.02.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.123083"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025295"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(01)02836-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.01.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.06.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1254-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90129-5"},{"key":"e_1_2_7_17_1","volume-title":"The Asia\u2010Pacific Perspective: Redefining Obesity and Its Treatment","author":"World Health Organization. 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