{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:11:20Z","timestamp":1790039480469,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esophageal cancer is a highly prevalent cancer associated with low survival, especially among those with advanced disease. Second\u2010line (2L) treatment patterns and related clinical outcomes of patients with advanced esophageal squamous cell carcinoma (advESCC) treated in routine clinical care were examined globally and regionally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, noninterventional study collected physician\u2010provided chart data of patients aged \u226520\u2009years receiving either 2L active systemic therapy or BSC following first\u2010line active therapy for advESCC from 11 countries in Asian and Western regions (September\u2013October 2018). Bivariate analyses examined treatment and outcomes by region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AdvESCC patients (Asia\u00a0=\u00a0192; West\u00a0=\u00a0195) were examined, of which 58.1% (Asia\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009101; West\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009124) received active systemic therapy. While regional differences in tumor classification and staging at diagnosis were observed with less advanced tumors in Asia, no regional differences for these characteristics at 2L initiation were reported. Both taxane\u2010 and nontaxane\u2010based therapies were used as 2L therapy among Asian and Western patients, although more western than Asian patients received immuno\u2010 or targeted therapies (17.0% vs. 3.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.001). Alopecia (10.7%), neutropenia (9.3%), and fatigue (9.3%) were the most\u2010commonly reported adverse events (AEs) in both regions. Significantly higher 2L AE\u2010related emergency room visits (Asia\u00a0=\u00a022.5% vs. West\u00a0=\u00a08.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) and hospitalizations (Asia\u00a0=\u00a025.9\u00a0\u00b1\u200931.2 vs. West\u00a0=\u00a04.7\u00a0\u00b1\u20097.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) were observed in Asian than in Western patients. No regional differences were reported for response to 2L treatment or the percent of patients who received third\u2010line treatment\/died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While regional variations were observed throughout the course of a patient's advESCC journey, disease response and treatment outcomes were similar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.14334","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T02:41:30Z","timestamp":1648694490000},"page":"1240-1257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A global perspective in\n                    <scp>second\u2010line<\/scp>\n                    treatment patterns for patients with advanced esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-037X","authenticated-orcid":false,"given":"Dena H.","family":"Jaffe","sequence":"first","affiliation":[{"name":"RWE Cerner Enviza  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gricar","sequence":"additional","affiliation":[{"name":"WWHEOR Bristol\u2010Myers Squibb  Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"DeCongelio","sequence":"additional","affiliation":[{"name":"Research and Consulting Cerner Enviza  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"deMauri S.","family":"Mackie","sequence":"additional","affiliation":[{"name":"RWE Cerner Enviza  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"International Agency for Research on Cancers (IARC). 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