{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:47:34Z","timestamp":1788961654476,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic implications of palliative chemotherapy for advanced or recurrent thymic carcinomas require full elucidation. The lung immune prognostic index (LIPI) is a novel prognostic index whose effectiveness has recently been reported in lung cancer patients. This study aimed to evaluate the clinical value of the LIPI in advanced or recurrent thymic carcinoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 41 advanced or recurrent thymic carcinoma patients undergoing palliative chemotherapy between January 2001 and December 2020. Survival\u2010time analysis was conducted using the Kaplan\u2013Meier method and log\u2010rank test. Multivariate analysis using the Cox proportional hazards model was performed to investigate the predictive and\/or prognostic value of the LIPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median progression\u2010free survival (PFS) for first\u2010line chemotherapy and overall survival (OS) were significantly longer in the good\u2010LIPI group (LIPI: 0) than in the intermediate\/poor\u2010LIPI group (LIPI: 1 or 2) (PFS: 13.4 vs. 6.8\u2009months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025; OS: 48.2 vs. 28.9\u2009months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.00506). Multivariate analysis revealed that intermediate\/poor LIPI was the adverse prognostic factor for PFS. With regard to OS, serum albumin &lt;3.5\u00a0g\/dl and an intermediate\/poor LIPI were identified as independent adverse prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicates that the LIPI is a potential prognostic marker in patients with advanced or recurrent thymic carcinoma undergoing palliative chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14349","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T06:31:05Z","timestamp":1644820265000},"page":"1006-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of lung immune prognostic index with survival outcome in advanced thymic carcinoma patients treated with palliative intent chemotherapy"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-868X","authenticated-orcid":false,"given":"Taisuke","family":"Araki","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-640X","authenticated-orcid":false,"given":"Kazunari","family":"Tateishi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Komatsu","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9810-4016","authenticated-orcid":false,"given":"Kei","family":"Sonehara","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-3928","authenticated-orcid":false,"given":"Shintaro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-0960","authenticated-orcid":false,"given":"Tomonobu","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyz203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000128"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.11.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/149185"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0383-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90246-9"},{"key":"e_1_2_7_9_1","first-page":"99","article-title":"The prognostic value of the C\u2010reactive protein to albumin ratio in cancer: an updated meta\u2010analysis","volume":"14","author":"Cui 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