{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:53:21Z","timestamp":1749516801224,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of tumor volume on prognosis is unclear. We therefore investigated the correlation between tumor volume and prognosis in patients with complete resection of thymoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 177 patients who underwent curative surgical resection for thymoma were retrospectively collected and reviewed. We performed a volumetric analysis of each case using the modified version of \u201cWatchin GGO\u201d and evaluated the relationship between tumor volume and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median tumor size was 5.0 (range 0.5\u201315) cm, and the median tumor volume was 35.1 (range 0.265\u2013881.0) cm<jats:sup>3<\/jats:sup>. The Pearson product\u2013moment correlation coefficient was 0.658, suggesting a moderately strong connection between tumor volume and tumor size. To determine the impact of tumor volume on tumor recurrence, receiver operating characteristic curves of the recurrence and tumor volume were calculated. The area under the curve was 0.65 (95% confidence interval [CI]: 0.51\u20130.80), and the optimal cutoff level of the tumor volume for recurrence was 82.6\u00a0cm<jats:sup>3<\/jats:sup>, with a sensitivity and specificity of 0.64 (11\/17) and 0.74 (119\/160), respectively. Patients with tumors \u226582.6\u00a0cm<jats:sup>3<\/jats:sup> had a significantly worse recurrence\u2010free survival than those with smaller tumors (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0122, hazard ratio: 2.99), with 5\u2010year recurrence rates of 74.9% (95% CI: 58.6%\u201386.3%) versus 88.9% (95% CI: 79.0%\u201394.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The volume of completely resectable thymoma may be a useful prognostic indicator.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14353","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T11:14:22Z","timestamp":1644923662000},"page":"1021-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic impact of tumor volume in patients with complete resection of thymoma"],"prefix":"10.1111","volume":"13","author":[{"given":"Yudai","family":"Miyashita","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2955-1490","authenticated-orcid":false,"given":"Takashi","family":"Kanou","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of 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