{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:17:58Z","timestamp":1778102278957,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herein, we report a case of a 73\u2010year\u2010old female patient diagnosed with cT4N0M1a lung adenocarcinoma with <jats:italic>KRAS<\/jats:italic> G12C mutation, PDL1\u2009&lt;\u20091% and treated in fourth\u2010line setting with gemcitabine after progression under nivolumab. After one infusion of gemcitabine, the patient presented with an acute worsening of general condition (performance status 4) with extensive skin lesions and fever, leading to hospitalization and diagnosis of acute generalized exanthematous pustulosis. Initial blood work revealed multiple organ failures with an important inflammatory syndrome. Patient state improved after intravenous hydration and local and systemic corticosteroids. The decision was made to stop systemic cancer treatment. Two months follow\u2010up showed a remarkable response on all cancer localizations. Although immunotherapy is transforming cancer care, predicting response to immunotherapy remains challenging and resistant mechanisms remain mostly unknown. This case underlines that important immune\u2010stimulation can lead to tumor response in a patient previously refractory to all antitumor treatments.<\/jats:p>","DOI":"10.1111\/1759-7714.14405","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T07:40:46Z","timestamp":1653550846000},"page":"1994-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute generalized exanthematous pustulosis caused by gemcitabine after nivolumab in metastatic lung adenocarcinoma followed by a dramatic tumor response: A case report"],"prefix":"10.1111","volume":"13","author":[{"given":"Pierre","family":"Magdelaine","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases and Thoracic Oncology APHP \u2013 Hopital Ambroise Pare  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Thoracic Oncology APHP \u2013 Hopital Ambroise Pare  Boulogne\u2010Billancourt France"},{"name":"University Paris\u2010Saclay, UVSQ, EA 4340 BECCOH  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Fabre","sequence":"additional","affiliation":[{"name":"Department of pathology APHP\u2010Hopital Ambroise Pare  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-1701","authenticated-orcid":false,"given":"Etienne","family":"Giroux\u2010Leprieur","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Thoracic Oncology APHP \u2013 Hopital Ambroise Pare  Boulogne\u2010Billancourt France"},{"name":"University Paris\u2010Saclay, UVSQ, EA 4340 BECCOH  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"issue":"5","key":"e_1_2_6_2_1","first-page":"239","article-title":"Association between immune\u2010related dermatologic adverse events and efficacy of pembrolizumab in non\u2010small cell lung cancer patients","volume":"76","author":"Fukuoka T","year":"2021","journal-title":"Pharmazie"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2925"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.9002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102134"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081214"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5390"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.005781.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.06.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.11.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14282"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00120-2017"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:28:01Z","timestamp":1692948481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":11,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/1759-7714.14405"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14405","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"2022-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}