{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:09:38Z","timestamp":1792793378826,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this prospective, pilot, single\u2010arm phase II trial was to evaluate the safety and efficacy of anlotinib combined with etoposide and platinum\u2010based regimens in the first\u2010line treatment of extensive\u2010stage small cell lung cancer (ES\u2010SCLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This phase II study was conducted at Fudan University Shanghai Cancer Center between December 2018 and December 2020. All patients received standard chemotherapy (etoposide plus cisplatin\/carboplatin) consisting of four courses and anlotinib at 12\u2009mg once per day for 2\u2009weeks followed by a one\u2010week rest. Anlotinib administration was continued until disease progression, intolerable adverse events (AEs) or patient withdrawal from the study. The primary outcome measure was progression\u2010free survival (PFS). The secondary outcome measures were overall survival (OS), objective control rate (ORR), disease control rate (DCR) and AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients were included in this study, and 30 patients were eligible for efficacy analysis. ORR and DCR were 90.0% and 96.7%, respectively. The estimated PFS and OS were 6.0\u00a0months (95% CI: 1.1\u201311.9\u00a0months) and 14.0\u00a0months (95% CI: 8.6\u201319.4\u00a0months), respectively. No unexpected adverse effects were reported. Hypertension (20\/37, 54.1%), anemia (16\/37, 43.2%), alopecia (15\/37, 40.5%), elevated transaminases (9\/37, 24.3%) and alkaline phosphatase (9\/37, 24.3%) were the most commonly reported AEs. Thirteen patients (35.1%) reported grade 3\u20135 AEs. No treatment\u2010related deaths occurred during this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of anlotinib to standard etoposide\/platinum chemotherapy achieved encouraging PFS and OS in previously untreated ES\u2010SCLC patients, with an acceptable tolerability profile and no new safety signals observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14414","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T11:29:21Z","timestamp":1649330961000},"page":"1463-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A phase <scp>II<\/scp> study of anlotinib combined with etoposide and platinum\u2010based regimens in the first\u2010line treatment of extensive\u2010stage small cell lung cancer"],"prefix":"10.1111","volume":"13","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of 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