{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:28Z","timestamp":1747182628487,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is often difficult to distinguish between thymoma and thymic carcinoma by preoperative radiological tests. While there have been some reports that the maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>) in positron emission tomography\u2010computed tomography (PET\u2010CT) is useful to this end, no large\u2010scale analysis has been performed. We therefore analyzed the usefulness of the SUV<jats:sub>max<\/jats:sub> and tumor size (TS) for differentiating thymic epithelial tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2011 to 2019, 129 patients with thymic epithelial tumor who underwent PET\u2010CT before surgical treatment were enrolled. The relevance of the SUV<jats:sub>max<\/jats:sub> to the World Health Organization (WHO) histological type was assessed. To reduce the impact of the TS, the ratio of the SUV<jats:sub>max<\/jats:sub> to the TS was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 99 thymoma cases and 30 thymic carcinoma cases were enrolled into the study. The SUV<jats:sub>max<\/jats:sub> and SUV<jats:sub>max<\/jats:sub>\/TS of thymic carcinoma were significantly higher than those of thymoma (SUV<jats:sub>max<\/jats:sub>: 7.7\u2009\u00b1\u20093.4 vs. 3.3\u2009\u00b1\u20091.3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; SUV<jats:sub>max<\/jats:sub>\/TS: 1.5\u2009\u00b1\u20090.7 vs. 0.6\u2009\u00b1\u20090.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Focusing on the patients with a moderate SUV<jats:sub>max<\/jats:sub> of \u22645 (84 thymoma and 4 thymic carcinoma), the SUV<jats:sub>max<\/jats:sub>\/TS values of thymic carcinoma were still significantly higher than those of thymoma (1.6\u2009\u00b1\u20090.8 vs. 0.6\u2009\u00b1\u20090.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PET\u2010CT might provide significant information for differentiating images of thymoma and thymic carcinoma. We experienced several cases of thymic carcinoma with a moderate SUV<jats:sub>max<\/jats:sub> of \u22645, and SUV<jats:sub>max<\/jats:sub>\/TS was considered a useful parameter for differentiating such cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14434","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T06:42:50Z","timestamp":1650696170000},"page":"1651-1656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Usefulness of positron\u2010emission tomography for predicting the World Health Organization grade of thymic epithelial tumors"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2955-1490","authenticated-orcid":false,"given":"Takashi","family":"Kanou","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Osaka 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Osaka 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