{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:47:04Z","timestamp":1784958424115,"version":"3.55.0"},"reference-count":6,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Targeted therapy offers a new option for patients with advanced lung adenocarcinoma patients. However, long\u2010term targeted therapy may transform lung adenocarcinoma into small cell lung cancer (SCLC). Herein, we report a 48\u2010year\u2010old female patient with pulmonary adenocarcinoma and ureteral metastasis which transformed from adenocarcinoma to SCLC after surgical and targeted therapies. She was diagnosed with invasive adenocarcinoma undergoing the surgery. Two years later recurrence and metastasis occurred and she was given targeted therapy with gefitinib and osimertinib. Two years after targeted therapy, a right ureteral mass (4.9\u2009\u00d7\u20093.7\u2009\u00d7\u20093.8\u00a0cm) pathologically diagnosed with SCLC was found, which indicated that the pathological subtype has changed from adenocarcinoma to SCLC. Ultimately, multiple metastases occurred after two cycles of chemotherapy consisting of cis\u2010platinum plus etoposide.<\/jats:p>","DOI":"10.1111\/1759-7714.14435","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T04:42:39Z","timestamp":1650343359000},"page":"1731-1734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ureteral metastasis of small cell lung cancer transformed from lung adenocarcinoma: A case report"],"prefix":"10.1111","volume":"13","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-3480","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-6346","authenticated-orcid":false,"given":"Guowei","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-8187","authenticated-orcid":false,"given":"Xiaoyang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First People's Hospital of Neijiang Neijiang Affiliated Hospital of Chongqing Medical University  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.08.06"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx705"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.02.006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002752"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(79)90075-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002752"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14435","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:27:18Z","timestamp":1692883638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/1759-7714.14435"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14435","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"2022-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}