{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:43:25Z","timestamp":1783100605492,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peutz\u2013Jeghers syndrome (PJS) is characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyposis, which can lead to intussusception. PJS patients face high lifetime risks for various cancer types, with the majority of patients being diagnosed with tumors along the gastrointestinal tract. Herein, we present the case of a 34\u2010year\u2010old man who carried a germline <jats:italic>STK11<\/jats:italic> pathogenic variant, while lacking the cardinal features of PJS syndrome. Interestingly, he was diagnosed with lung adenocarcinoma despite being a never\u2010smoker. Tumor testing revealed clinically relevant molecular alterations, including the known germline pathogenic variant <jats:italic>STK11<\/jats:italic>, a <jats:italic>KRAS<\/jats:italic> somatic pathogenic variant, and <jats:italic>FGFR3<\/jats:italic> gene amplification. Treatment with standard chemotherapy and immunotherapy did not have a clinical benefit. Due to clinical deterioration, the patient deceased 18\u2009months after his initial diagnosis prior to having the chance for targeted therapy. Identification of rare hereditary cancer syndromes and the respective presence of tumor biomarkers can provide important alternatives to targeted treatments, including immunotherapy in patients with tumors unresponsive to conventional treatment protocols. This case highlights that although only a small proportion of lung cancer diagnoses will be due to hereditary predisposition, <jats:italic>STK11<\/jats:italic> germline carriers should be under close surveillance for early detection of lung cancer.<\/jats:p>","DOI":"10.1111\/1759-7714.14447","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:42:24Z","timestamp":1652265744000},"page":"1862-1865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung cancer as a predominant feature in a patient with <scp>Peutz\u2013Jeghers<\/scp> syndrome: Case report"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-2332","authenticated-orcid":false,"given":"Florentia","family":"Fostira","sequence":"first","affiliation":[{"name":"Molecular Diagnostics Laboratory InRASTES, National Centre for Scientific Research Demokritos  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fountzilas","sequence":"additional","affiliation":[{"name":"Second Department of Medical Oncology Euromedica General Clinic of Thessaloniki  Thessaloniki Greece"},{"name":"European University Cyprus German Oncology Center  Limassol Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology Hellenic Foundation for Cancer Research\/Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Karaiskos","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Department Papanikolaou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Mpatsi","sequence":"additional","affiliation":[{"name":"Pathology Department 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Thessaloniki  Thessaloniki Greece"},{"name":"Department of Medical Oncology German Oncology Center  Limassol 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