{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:05:52Z","timestamp":1778065552993,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current predictive tools assess catheter\u2010related thrombosis (CRT) in patients with lung cancer in a static manner at a single time point of catheterization. The subsequent hazard changes over time are unknown. The conditional catheter\u2010related thrombosis\u2010free probability (CCFP) can provide dynamic information on continual CRT\u2010free expectations. This study aimed to assess the CCFP and hazard rates based on risk categories and various venous access devices (VADs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study reviewed 939 patients with lung cancer with peripherally inserted central venous catheters (PICCs) or central venous catheters (CVCs) identified at the National Clinical Research Center for Cancer between January 1, 2015 and December 31, 2018. The incidence of CRT has also been reported. Patients were stratified into low\u2010 and high\u2010risk groups according to multivariate Cox regression analyses. CCFP is defined as the CRT\u2010free probability given that patients have no CRT for a definite time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 507 patients with PICCs and 432 patients with CVCs were included in this study. The 3\u2010month CCFP increased from 74.2% at catheter insertion to 93.6% at 3\u00a0months. The hazards of CRT in the first month were highest (16.4%) and slightly thereafter. The high\u2010risk group initially had a higher (21.4%) but significantly decreased CRT hazard after 2\u00a0months (8.3%), whereas the low\u2010risk group maintained a comparable lower risk hazard of less than 5% after 1\u00a0month. In the overall cohort, patients with CVCs had lower CRT probability than those with PICCs (HR, 1.76; 95% CI: 1.28\u20132.41; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Further analysis demonstrated that compared with PICCs, CVCs provided a CRT\u2010free benefit in low\u2010risk patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) but not in high\u2010risk patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CCFP increased, and the hazards of CRT decreased over time in a risk\u2010dependent manner in patients with lung cancer. These valuable dynamic data may help optimize risk\u2010adjusted choices of VADs and risk\u2010adjusted prophylactic anticoagulation strategies for patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14460","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T05:43:35Z","timestamp":1652507015000},"page":"1814-1821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conditional <scp>catheter\u2010related<\/scp> thrombosis free probability and risk\u2010adapted choices of catheter for lung cancer"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-9851","authenticated-orcid":false,"given":"Yanfeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Comprehensive Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanjuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5919-5074","authenticated-orcid":false,"given":"Lei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Cancer Hospital of Huanxing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Management Center Cancer Hospital of Huanxing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Management Center Cancer Hospital of Huanxing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Management Center Cancer Hospital of Huanxing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-5091","authenticated-orcid":false,"given":"Wei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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