{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:47:17Z","timestamp":1761061637050,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007632","name":"Changhua Christian Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying patients with stage I non\u2010small cell lung cancer (NSCLC) at increased risk of tumor recurrence following surgery remains a major challenge. The current study aimed to compare disease\u2010free survival (DFS) rates after surgery between patients with clinically node\u2010positive (cN+) and \u2010negative (cN0) stage I NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with pathological stage I resected NSCLC were identified from the lung cancer database of Changhua Christian Hospital in Taiwan. Patients with clinical N status 1 or 2 and pathological N status 0 were identified as the cN+\/pN0 cohort, whereas others were identified as the cN0\/pN0 cohort. Propensity score matching (PSM) was used to balance the baseline characteristics between both cohorts. Kaplan\u2013Meier method and Cox proportional hazards model were used to evaluate DFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2010 to July 2019, 754 eligible patients were enrolled into the study, among whom 41 (5.4%) were cN+\/pN0. The median follow\u2010up time was 43.4\u2009months. Before PSM, the 5\u2010year DFS rate was 79.0% and 90.3% in cN+\/pN0 and cN0\/pN0 cohorts (log\u2010rank test,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009), respectively. After a 1:4 PSM, multivariate analysis showed that the cN+\/pN0 cohort still had a poorer DFS compared to the cN0\/pN0 cohort in (hazard ratio, 3.17;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with stage I resected NSCLC, cN+ patients had a worse DFS compared to cN0 patients. Surgeons should therefore consider more aggressive adjuvant therapy or frequent follow\u2010up in patients with surgically resected stage I NSCLC with cN+ status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14462","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T03:44:16Z","timestamp":1652845456000},"page":"1933-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of recurrence risk between patients with clinically node\u2010positive and \u2010negative stage I non\u2010small cell lung cancer following surgery: A propensity score matching analysis"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-1282","authenticated-orcid":false,"given":"Kuo\u2010Yang","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan"},{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan"},{"name":"Ph.D. Program in Medical Biotechnology National Chung Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-9021","authenticated-orcid":false,"given":"Hung\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Internal Medicine China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine, College of Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Hsiung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan"},{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1603-5406","authenticated-orcid":false,"given":"Sheng\u2010Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan"},{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan"},{"name":"Department of Recreation and Holistic Wellness MingDao University Changhua 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