{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:15:55Z","timestamp":1785147355526,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to explore the predictability of topological signatures linked to the locoregional relapse (LRR) and distant metastasis (DM) on pretreatment planning computed tomography images of stage I non\u2010small cell lung cancer (NSCLC) patients before treatment with stereotactic ablative radiotherapy (SABR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We divided 125 primary stage I NSCLC patients (LRR: 34, DM: 22) into training (<jats:italic>n<\/jats:italic> = 60) and test datasets (<jats:italic>n<\/jats:italic>\u2009=\u200965), and the training dataset was augmented to 260 cases using a synthetic minority oversampling technique. The relapse predictabilities of the conventional wavelet\u2010based features (WF), topology\u2010based features [BF, Betti number (BN) map features; iBF, inverted\u00a0BN map features], and their combined features (BWF, iBWF) were compared. The patients were stratified into high\u2010risk and low\u2010risk groups using the medians of the radiomics scores in the training dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the LRR in the test, the iBF, iBWF, and WF showed statistically significant differences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and the highest nLPC was obtained for the iBF. For the DM in the test, the iBWF showed a significant difference and the highest nLPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The iBF indicated the potential of improving the LRR and DM prediction of stage I NSCLC patients prior to undergoing SABR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14483","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T04:40:06Z","timestamp":1655440806000},"page":"2117-2126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relapse predictability of topological signature on pretreatment planning <scp>CT<\/scp> images of stage I non\u2010small cell lung cancer patients before treatment with stereotactic ablative radiotherapy"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8134-0837","authenticated-orcid":false,"given":"Takumi","family":"Kodama","sequence":"first","affiliation":[{"name":"Division of Medical Quantum Science, Department of Health Sciences, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Arimura","sequence":"additional","affiliation":[{"name":"Division of Medical Quantum Science, Department of Health Sciences, Faculty of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamasa","family":"Yoshitake","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center, SAGA HIMAT Foundation  Tosu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_3_1","first-page":"56","article-title":"Lung cancer: diagnosis and management","volume":"75","author":"Collins LG","year":"2007","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13103"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.09.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12352"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.05.055"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1751"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31196"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14380"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151829"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.12.369"},{"key":"e_1_2_7_14_1","first-page":"66","article-title":"Cavitated tumor as a clinical subentity in squamous cell lung cancer patients","volume":"50","author":"Kolodziejski LS","year":"2003","journal-title":"Neoplasma"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.04.019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27707-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2019.11.026"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244354"},{"key":"e_1_2_7_20_1","volume-title":"Computational phenotypes: towards an evolutionary developmental biolinguistics, Computational Homology","author":"Balari S, Lorenzo G, Gonzalez G.","year":"2013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/38.135915"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/60\/14\/5471"},{"key":"e_1_2_7_23_1","unstructured":"GitHub 2015 MATLAB programming tools for radiomics analysis"},{"key":"e_1_2_7_24_1","unstructured":"Glmnet v4.1\u20131.2021;https:\/\/rdocumentation.org\/packages\/glmnet. Accessed 9 Nov 2021."},{"key":"e_1_2_7_25_1","unstructured":"Survival v3.2\u20137.2020;https:\/\/www.rdocumentation.org\/packages\/survival. Accessed 9 Nov 2021."},{"key":"e_1_2_7_26_1","unstructured":"Hmisc v4.1\u20131.2018;https:\/\/rdocumentation.org\/packages\/Hmisc. Accessed 9 Nov 2021."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13202"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1613\/jair.953"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2016.07.018"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.746785"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1251"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20\u2009713-6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.10.015"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:23:08Z","timestamp":1692836588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,16]]},"references-count":33,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/1759-7714.14483"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14483","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,16]]},"assertion":[{"value":"2022-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}