{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:26:08Z","timestamp":1772004368392,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies have shown that several systemic inflammatory markers and the nutrition status, including the neutrophil\u2010to\u2010lymphocyte ratio (NLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic factors in several malignant tumors. The present study explored the prognostic value of the NLR, MLR, PLR, and PNI in thymic epithelial tumor (TET) patients who underwent complete resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 158 TET patients who underwent complete resection were involved in the analysis. Their NLR, MLR, PLR, and PNI values were obtained from a blood examination within one month before the initiation of treatment. A receiver operating characteristic curve analysis was conducted to determine the optimal cutoff values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The enrolled patients were stratified by cutoffs of 4.35 for the NLR, 0.22 for the MLR, 130.18 for the PLR, and 44.02 for the PNI. A univariate analysis revealed that high\u2010grade malignant TET, including type B2 and B3 thymoma, thymic carcinoma, and thymic neuroendocrine tumor; an advanced Masaoka stage; a high NLR; a high MLR; and a low PNI were significant predictors of a poor disease\u2010free survival (DFS). A multivariate analysis confirmed that an advanced Masaoka stage (HR\u00a0=\u00a05.5557, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0007) and a high MLR (HR\u00a0=\u00a03.3371, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0264) were independent predictors of a poor DFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that the pretreatment MLR was an independent predictor of the DFS in patients with TETs who underwent complete resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14485","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T07:09:38Z","timestamp":1655536178000},"page":"2127-2133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection"],"prefix":"10.1111","volume":"13","author":[{"given":"Tadashi","family":"Sakane","sequence":"first","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-2348","authenticated-orcid":false,"given":"Katsuhiro","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Tatematsu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.01.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24561"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-02059-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24523"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.07.024"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0794-1"},{"key":"e_1_2_6_11_1","first-page":"1001","article-title":"Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients","volume":"85","author":"Onodera T","year":"1984","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2020.2117"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1714-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4049\/jimmunol.134.1.230","article-title":"Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes","volume":"134","author":"Petrie HT","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.4049\/jimmunol.139.7.2406","article-title":"Immunosuppression by activated human neutrophils. 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