{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:41Z","timestamp":1747182641021,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of lung cancer patients with interstitial lung disease (ILD) is poor, and acute exacerbation (AE) of ILD can occur during chemotherapy as a fatal adverse event. Although AE\u2010ILD development is correlated with various factors, no reports are investigating the disease activity of lung cancer at the time of AE\u2010ILD development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive lung cancer patients with ILD who developed chemotherapy\u2010related AE\u2010ILD within 28\u2009days after the last administration of cytotoxic chemotherapy between 2011 and 2020 were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 206 lung cancer patients with ILD who were treated with cytotoxic chemotherapy, 30 patients were included. The median age was 72\u2009years and all patients were men with smoking history. Usual interstitial pneumonia (UIP) and non\u2010UIP patterns of ILD was observed in 17 and 13 patients. Most of AE\u2010ILD occurred during second\u2010 or later\u2010line (22\/30, 73.3%) and developed within first or second courses during chemotherapy (19\/30, 63.3%). Regarding tumor response to chemotherapy at AE\u2010ILD development, majority of patients (18 patients, 60.0%) experienced progressive disease and only one patient (3.3%) experienced a partial response. Notably, 27 patients (90.0%) did not exhibit any tumor shrinkage of the thoracic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lung cancer was uncontrolled with cytotoxic chemotherapy at the time of AE\u2010ILD development. Although AE\u2010ILD during chemotherapy has been generally discussed in terms of drug\u2010specific adverse effects, uncontrolled lung cancer may be also correlated with AE\u2010ILD development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14566","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T01:14:10Z","timestamp":1657934050000},"page":"2443-2449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disease activity of lung cancer at the time of acute exacerbation of interstitial lung disease during cytotoxic chemotherapy"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-8561","authenticated-orcid":false,"given":"Akimasa","family":"Sekine","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Kanagawa 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