{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:40Z","timestamp":1747182640994,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The safety of neoadjuvant chemoimmunotherapy before surgery in patients with non\u2013small cell lung cancer (NSCLC) remains unclear in the perioperative stage. We describe a case of a 63\u2010year\u2010old man with IIIC stage NSCLC who received neoadjuvant chemoimmunotherapy and radical lobectomy. After the second cycle of pembrolizumab and chemotherapy (paclitaxel + carboplatin), the patient was diagnosed with immunologic enterocolitis and relieved by glucocorticoid therapy. Radical lobectomy of the right upper lobe was then performed. On postoperative day 4 (POD 4), the patient suddenly suffered suffocated wheezing during sleep. Interstitial lung disease was, therefore, identified by chest computed tomography scan. Glucocorticoids and mechanical ventilation were applied and the symptoms were relieved. On POD 10, the patient developed a bronchial fistula and underwent emergent repair surgery. This is the first case of multi\u2010organs, multi\u2010time point immune\u2010related adverse events (irAE) in perioperative NSCLC patients who received neoadjuvant chemoimmunotherapy. Clinicians should be on high alert for signs of irAEs in neoadjuvant chemoimmunotherapy patients, promptly requiring multidisciplinary management.<\/jats:p>","DOI":"10.1111\/1759-7714.14567","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T08:14:20Z","timestamp":1657527260000},"page":"2340-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi\u2010organs perioperative <scp>immune\u2010related<\/scp> adverse events and postoperative bronchial anastomotic fistula in a patient receiving neoadjuvant immunotherapy with <scp>NSCLC<\/scp>"],"prefix":"10.1111","volume":"13","author":[{"given":"Yuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Science  Beijing 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