{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:42Z","timestamp":1747182642633,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thymic epithelial tumors (TETs) exhibit irregular shapes reflective of the heterogeneity in tumor growth and invasive properties. We aimed to identify the prognostic value of the pathological tumor long\u2010to\u2010short axis (L\/S) ratio in TETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed on patients with TETs who underwent extended thymectomy between January 1999 and December 2019 in our institute. Patients were divided into two groups according to the threshold of the L\/S ratio. Overall survival (OS) and progression\u2010free survival (PFS) were evaluated by Kaplan\u2010Meier analysis. The independent prognostic factors of TETs were identified by multivariate analysis. The performance of prediction models for the above survival outcomes with and without the L\/S ratio was evaluated using an integrated time\u2010dependent area under the curve (iAUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eligible patients were divided into two groups based on higher (<jats:italic>n<\/jats:italic> =\u200942) and lower (<jats:italic>n<\/jats:italic> =\u200994) L\/S ratios according to a threshold value of 1.39. A significant difference was found between the two groups only in disease progression (<jats:italic>p<\/jats:italic> =\u20090.001). Poorer survival outcomes were found from Kaplan\u2010Meier curves in the higher L\/S ratio group (<jats:italic>p<\/jats:italic> &lt;\u20090.05). In the multivariable analysis, the L\/S ratio showed significant effects on OS and PFS (<jats:italic>p<\/jats:italic> &lt;\u20090.05). The performance of models with the L\/S ratio was better than that without the L\/S ratio in predicting survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathological tumor L\/S ratio is an independent prognostic factor for OS and PFS in patients with TETs, and an L\/S ratio &gt;1.39 is associated with worse survival outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14582","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T08:50:16Z","timestamp":1658393416000},"page":"2489-2498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathological tumor long\u2010to\u2010short axis ratio as a prognostic factor in patients with thymic epithelial tumors"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-8309","authenticated-orcid":false,"given":"Dong","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Academician (Expert) Workstation Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7736","authenticated-orcid":false,"given":"Haruhiko","family":"Shiiya","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Cardiovascular and Thoracic Surgery Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Shinozaki\u2010Ushiku","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Ji","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Medical Image North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1f62d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07330-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000303"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000300"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31821e7b12"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13188"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09127-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000290"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs055"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.03.01"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-019-00825-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2012.08.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000654"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03218097"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.04.070"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.05.048"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f13682"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00337.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt649"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200105000-00010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.10.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-009-0478-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.2.1830283"},{"issue":"1","key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"v","DOI":"10.1016\/j.thorsurg.2010.08.008","article-title":"Prediction of thymoma histology and stage by radiographic criteria","volume":"21","author":"Yanagawa M","year":"2011","journal-title":"Thorac Surg Clin"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102897"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr026"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25462"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08228-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-017-1283-4"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0245-RA"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.03.24"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10226"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.01.026"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:39:31Z","timestamp":1692639571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/1759-7714.14582"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14582","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2022-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}