{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T17:49:05Z","timestamp":1749059345755,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Combination chemotherapy is used to treat advanced thymic carcinoma; however, the effects are insufficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Previously untreated patients with unresectable locally advanced thymic carcinoma received two cycles of 80\u2009mg\/m<jats:sup>2<\/jats:sup>\/day S\u20101 orally on days 1\u201314 plus 60\u2009mg\/m<jats:sup>2<\/jats:sup>\/day cisplatin intravenously on day 1, and concurrent radiotherapy (60\u2009Gy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients were enrolled into the study. Toxicity and survival were assessable in all patients, but the treatment response was only assessable in one patient. The study was terminated because of poor case recruitment. The patients' characteristics were as follows: male\/female\u00a0=\u00a02\/1; PS 0\/1\u00a0=\u00a02\/1; median age (range)\u00a0=\u00a059 (55\u201372); and stage III\/IV\u00a0=\u00a02\/1. The patient in which the treatment response was assessed exhibited SD (response rate: 0%). In both nonevaluable cases, the second course of chemotherapy was judged to be post\u2010protocol treatment because it was delayed by \u226514\u2009days, but a CR and PR were achieved after the end of the study, respectively. G4 leukopenia\/neutropenia and G3 febrile neutropenia occurred in one patient each (33%). The median time to tumor progression was 17.6\u00a0months, and the 1\u2010, 2\u2010, 3\u2010, and 4\u2010year survival rates were 67, 33, 33, and 33%, respectively. The median overall survival time was not reached, and the 1\u2010, 2\u2010, 3\u2010, and 4\u2010year survival rates were 100, 67, 67, and 67%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although it was difficult to recruit patients, there was a long\u2010term survivor &gt;4\u2009years who appeared to have achieved a CR, indicating that such chemoradiotherapy may be effective against locally advanced thymic carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14586","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T06:29:29Z","timestamp":1658557769000},"page":"2499-2506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phase <scp>II<\/scp> study of S\u20101 plus cisplatin with concurrent radiotherapy for locally advanced thymic carcinoma: Results of the <scp>LOGIK1605<\/scp>\/<scp>JART<\/scp>\u20101501 study"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-1843","authenticated-orcid":false,"given":"Minoru","family":"Fukuda","sequence":"first","affiliation":[{"name":"Cancer Treatment Center Nagasaki Prefecture Shimabara Hospital  Shimabara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Hospital Organization Kyusyu Cancer Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Funaki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Suita Osaka 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