{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:51:57Z","timestamp":1791899517012,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C2006282"],"award-info":[{"award-number":["2020R1A2C2006282"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is used to evaluate hilar\/interlobar\/lobar lymph nodes. This study aimed to assess the clinical utility of EBUS\u2010TBNA for station 10\/11\/12 lymph nodes (LNs) in patients with primary lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of a prospectively collected database of patients with primary lung cancer who underwent EBUS\u2010TBNA for station 10\/11\/12 LNs from January 2015 to December 2019. Patients with benign results from EBUS\u2010TBNA who did not undergo surgical sampling\/clinical follow\u2010up or who received radiotherapy\/chemotherapy were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analyses were conducted on 889 LNs from 797 patients. The overall diagnostic sensitivity, specificity, accuracy, negative predictive value (NPV), and positive predictive value of EBUS\u2010TBNA were 95.7, 100, 97.3, 93.2, and 100%, respectively. Diagnostic sensitivity was significantly lower for LNs &lt;10\u2009mm than \u226510\u2009mm in size (90.1% vs. 97.8%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no significant difference in diagnostic performance according to the nodal station (10 vs. 11\/12) and left\u2010 versus right\u2010sided LNs. The diagnostic sensitivity (100 vs. 95.5%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.221) and specificity (100 vs. 100%) of N3 LNs was not significantly different from those of N1 LNs. In this study, eight (8\/91, 8.8%) patients with cN1 NSCLC received neoadjuvant treatment based on the results of EBUS\u2010TBNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EBUS\u2010TBNA accurately evaluates station 10\/11\/12 LNs of both N1 and N3 disease. The diagnostic performances of EBUS\u2010TBNA for station 10\/11\/12 LNs seem to be comparable to those of EBUS\u2010TBNA for mediastinal LNs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14587","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T05:28:45Z","timestamp":1658381325000},"page":"2507-2514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical utility of <scp>EBUS\u2010TBNA<\/scp> of hilar, interlobar, and lobar lymph nodes in patients with primary lung cancer"],"prefix":"10.1111","volume":"13","author":[{"given":"Seungbum","family":"Wi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Guen","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hye","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Woo","family":"Jhun","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongseok","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong\u2010Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungjong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojoong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O Jung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joungho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhingook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9765-9068","authenticated-orcid":false,"given":"Sang\u2010Won","family":"Um","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Health Sciences and Technology, SAIHST Sungkyunkwan University  Seoul Republic of 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