{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:28:20Z","timestamp":1778077700356,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2022R1F1A1074912"],"award-info":[{"award-number":["2022R1F1A1074912"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma glucose levels might be associated with the severity of tumor hypoxia in patients with cancer. In our previous study, we found that chronic hyperglycemia significantly increased the risk of locoregional recurrence in patients with non\u2010small cell lung cancer treated with radical radiotherapy (RT). Here, we evaluated the association between plasma glucose levels in terms of hemoglobin A1c (HbA1c) and locoregional recurrence\u2010free survival in patients with limited\u2010stage small cell lung cancer treated with radical RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical data of 59 patients with small cell lung cancer. HbA1c levels were measured 1\u2009week before the start of RT. Survival outcomes were analyzed according to HbA1c levels. Multivariable analysis was conducted to identify whether HbA1c level was a significant prognostic factor for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1\u2010, 2\u2010, and 3\u2010year locoregional recurrence\u2010free survival rates were 90.9, 86.1, and 78.9%, respectively, in the low HbA1c group, and 45.1, 27.1, and 20.3%, respectively, in the high HbA1c group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 1\u2010, 2\u2010, and 3\u2010year distant metastasis\u2010free survival rates were 67.2, 57, and 57%, respectively, in the low HbA1c group, while it was 56.6, 24.9, and 24.9%, respectively, in the high HbA1c group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024). HbA1c level remained a significant prognostic factor for locoregional recurrence\u2010free survival in the multivariable analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic hyperglycemia is a significant prognostic factor for locoregional recurrence\u2010free survival in patients with limited\u2010stage small cell lung cancer treated with radical RT. Routine monitoring of plasma glucose levels and aggressive glycemic control should be conducted to prevent locoregional recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14601","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T10:43:30Z","timestamp":1659609810000},"page":"2633-2640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic hyperglycemia is an adverse prognostic factor for locoregional recurrence\u2010free survival in small cell lung cancer patients treated with radical radiotherapy"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-0417","authenticated-orcid":false,"given":"Moonkyoo","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Kyung Hee University Medical Center Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-8989","authenticated-orcid":false,"given":"Yu Jin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kyung Hee University Medical Center Kyung Hee University College of Medicine  Seoul Republic of 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