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Exosome delivery of drugs has shown great potential for targeted drug delivery in the treatment of various diseases. In the current study, we explored the approach of co\u2010delivering CDDP and CD47 antibody with MDA\u2010MB\u2010231 cell\u2010derived exosome 231\u2010exo (CaCE) and assessed the phagocytosis activity of bone marrow flow cytometry derived macrophages (BMDM) against co\u2010cultured A549 cells. CD8<jats:sup>+<\/jats:sup> T\u2010cell proliferation was examined with flow cytometry analysis. In vivo, we used the Lewis lung carcinoma (LLC) tumor\u2010bearing mouse model and assessed survival rate, tumor weight, phagocytosis, and T\u2010cell proliferation, as well as cytokine levels in tumors analyzed by enzyme\u2010linked immunoassay (ELISA). Although co\u2010administration of CDDP with anti\u2010CD47 (CDDP and aCD47) showed a significant antitumor effect, CaCE had an even more dramatic anticancer effect in survival rate and tumor weight. We observed increased phagocytosis activity selectively against lung tumor cells in vivo and in vitro with exosome CaCE treatment. CaCE treatment also increased T\u2010cell proliferation compared to the vehicle treatment and co\u2010administration groups. Furthermore, immunostimulatory interleukin (IL)\u201012p and interferon (IFN)\u2010\u03b3 were increased, whereas transforming growth factor \u03b2 (TGF\u2010\u03b2) were decreased, indicating the improved CDDP anticancer effect is related to a tumor microenvironmental change. Our study demonstrates a dramatically improved anticancer effect of CDDP when administered by exosome co\u2010delivery with anti\u2010CD47.<\/jats:p>","DOI":"10.1111\/1759-7714.14606","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T10:05:28Z","timestamp":1661594728000},"page":"2723-2731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Lung\u2010specific exosomes for co\u2010delivery of <scp>CD47<\/scp> blockade and cisplatin for the treatment of non\u2013small cell lung cancer"],"prefix":"10.1111","volume":"13","author":[{"given":"Zhilei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshang","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of 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