{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:59:06Z","timestamp":1792292346973,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune checkpoint inhibitor (ICI)\u2010based therapies have shown promising advances for the first\u2010line treatment of advanced or metastatic esophageal cancer (EC). However, few studies concerning the identification of patients who achieve durable response from ICIs have been previously reported. In the present study, pre\u2010 and on\u2010treatment plasma circulating tumor DNA (ctDNA) were analyzed in 10 patients with advanced esophageal squamous cell cancer (ESCC) receiving first\u2010line chemoimmunotherapy. Patients with decreased molecular tumor burden index (mTBI) &gt;7% experienced longer progression\u2010free survival (PFS) and durable clinical benefit (DCB, PFS \u2265\u20096\u2009months). In addition, five patients showed stable disease at first scan, all three patients with decreased mTBI &gt;\u20097% achieved DCB, while two cases with decreased mTBI \u2264\u20097% experienced non\u2010DCB. Our results demonstrate that ctDNA monitor might help identify which ESCC patients respond to chemoimmunotherapy.<\/jats:p>","DOI":"10.1111\/1759-7714.14610","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:39:47Z","timestamp":1661243987000},"page":"2786-2791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of durable chemoimmunotherapy response via circulating tumor <scp>DNA<\/scp> in advanced esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"13","author":[{"given":"Dongyang","family":"Yang","sequence":"first","affiliation":[{"name":"Secondary division of Medical Oncology, Cancer Center Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Secondary division of Medical 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