{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:49:32Z","timestamp":1766400572417,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Staging of the mediastinum lymph nodes involvement in patients with non\u2013small cell lung cancer (NSCLC) is an important prognostic factor determining the most appropriate multimodality treatment plan. The objective of this study is to assess ultrasound characteristics of mediastinal lymph nodes metastasis and effectiveness of intraoperative ultrasound\u2010guided mediastinal nodal dissection in patients with resected NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All patients undergoing video\u2010assisted thoracoscopic surgery lobectomy and pulmonary lymphadenectomy from November 2020 to March 2022 at the thoracic surgery department of the Vanvitelli University of Naples underwent intraoperative ultrasound\u2010guided mediastinal lymph nodal dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study evaluates whether individual B\u2010mode features and a compounding thereof can be used to accurately and reproducibly predict lymph node malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Intraoperative ultrasound, during systematic mediastinal lymph node dissection, is helpful in preventing lesion to mediastinal structures. Pathological nodal sonographic characteristics are round shape, short\u2010axis diameter, echogenicity, margin, the absence or presence of coagulation necrosis sign, and the absence or presence of central hilar structure, increased color Doppler flow, the absence or presence of calcification, and nodal conglomeration. Operating time was not substantially prolonged. The procedure is simple, safe and highly accurate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasonic techniques allow surgeons to detect the relationship between lymph nodes and surrounding large blood vessels during biopsy, improving the safety and simplicity of the operation, increasing the number of harvested lymph nodes, and reducing the risk of intraoperative injury; it is a fast, easily reproducible, and inexpensive method.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14623","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T06:41:03Z","timestamp":1666334463000},"page":"3250-3256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intraoperative ultrasound: \u201cAlternative eye\u201d in lymph nodal dissection in non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-7201","authenticated-orcid":false,"given":"Gaetana","family":"Messina","sequence":"first","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Bove","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Noro","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Opromolla","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Natale","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Mirra","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Capasso","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide Gerardo","family":"Pica","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pirozzi","sequence":"additional","affiliation":[{"name":"Oncology, Department of Precision Medicine Universit\u00e0 della Campania \u201cL. 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