{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:49Z","timestamp":1747182649927,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surgery is part of a multimodal therapeutic approach to malignant pleural mesothelioma (MPM) although its real beneficial effect is still controversial. The optimal precise sequence of treatments within the trimodality is unclear, and should be decided upon a multidisciplinary consensus for each individual patient. Here, we analyzed the perioperative data of 19 MPM patients who underwent extended pleurectomy\/decortication (EPD) with curative intent. The mean age at diagnosis was 67\u2009years; 11 males and eight females. Ten patients were diagnosed with MPM via medical thoracoscopy (MT), and nine via video\u2010assisted thoracoscopic surgery (VATS). The vast majority of cases harbored epitheliod forms. We compared neoadjuvant chemotherapy (NCT) followed by surgery (11 cases) versus surgery followed by adjuvant chemotherapy (ACT, 8 cases) within a 3\u2010year period. All patients had extended pleurectomy\/decortication and none had an extended pneumonectomy. Analysis of survival curves suggested that the short\u2010term outcomes are better with upfront EDP followed by ACT if compared to EDP preceded by NCT. Although limited, the data highlighted the safety and feasibility of EPD, with manageable postoperative complications and no major burden for the patients.<\/jats:p>","DOI":"10.1111\/1759-7714.14627","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:05:27Z","timestamp":1662109527000},"page":"2792-2798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility and safety of extended pleurectomy\/decortication for malignant pleural mesothelioma. A single group experience"],"prefix":"10.1111","volume":"13","author":[{"given":"Francesco","family":"Falanga","sequence":"first","affiliation":[{"name":"Department. of Intensive Medicine, Unit of Cardiothoracic Surgery IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department. of Intensive Medicine, Unit of Cardiothoracic Surgery IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Primiceri","sequence":"additional","affiliation":[{"name":"Department. of Intensive Medicine, Unit of Cardiothoracic Surgery IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Department of Clinical\u2010Surgical, Diagnostic and Paediatric Sciences University of Pavia Medical School  Pavia Italy"},{"name":"Department of Intensive Medicine, Unit of Radiology IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Oneta","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Infective Diseases, Unit of Radiation Therapy IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Agustoni","sequence":"additional","affiliation":[{"name":"Department of Intensive Medicine, Unit of Medical Oncology IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Morbini","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia Medical School  Pavia Italy"},{"name":"Unit of Pathology IRCCS Fondazione Policlinico San 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