{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:24:05Z","timestamp":1788312245042,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various advanced bronchoscopy methods have been developed to reach peripheral lung lesions (PLL). In a large cohort, we aimed to assess a standardized procedure of first\u2010line radial\u2010endobronchial ultrasound (r\u2010EBUS) and virtual bronchoscopy planner for the diagnosis of peripheral lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, single center study included patients who had r\u2010EBUS\u2010guided bronchoscopy for the diagnosis of a PLL between 2008 and 2019. Cases without a final diagnosis of cancer or follow\u2010up were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2008 and 2019, 2735 patients had a r\u2010EBUS procedure, among whom 1627 had a final diagnosis of cancer and were included in the present study. Over the 12\u2010year study period, r\u2010EBUS became the first\u2010line endoscopic procedure to assess PLL (25% as first\u2010line bronchoscopy in 2008 vs. 92% in 2019). The frequency of the bronchus sign decreased from 2009 to 2019 (100% to 80%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), whereas US visualization of the lesion remained stable (88%). The median number of biopsies increased from two (2008 to 2014) to four (2015 to 2019) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), with the same diagnostic efficiency (74% total and 80% when a bronchus sign was present). Of the 651 adenocarcinomas, molecular analysis was possible in 86%. PD\u2010L1 expression analysis was possible in 81% of cases. During the study period, the lifetime of the radial probe increased from 57 procedures to 77 procedures\/probe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because r\u2010EBUS and VB planner is easy to perform under local anesthesia, inexpensive and efficient it can be used as a first\u2010line procedure to assess peripheral lung cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14629","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T06:14:08Z","timestamp":1661840048000},"page":"2854-2860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>Radial\u2010EBUS<\/scp> and virtual bronchoscopy planner for peripheral lung cancer diagnosis: How it became the first\u2010line endoscopic procedure"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-0887","authenticated-orcid":false,"given":"Samy","family":"Lachkar","sequence":"first","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Gervereau","sequence":"additional","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"De Marchi","sequence":"additional","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Morisse Pradier","sequence":"additional","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Dantoing","sequence":"additional","affiliation":[{"name":"Department of Pneumology CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Piton","sequence":"additional","affiliation":[{"name":"Department of Pathology CHU Rouen  Rouen France"},{"name":"France and Normandie University, UNIROUEN, Inserm U1245, Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Thiberville","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Inserm CIC\u2010CRB Normandie Univ, UNIROUEN, LITIS Lab QuantIF team EA4108, CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-7303","authenticated-orcid":false,"given":"Florian","family":"Guisier","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Inserm CIC\u2010CRB Normandie Univ, UNIROUEN, LITIS Lab QuantIF team EA4108, CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Sala\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Inserm CIC\u2010CRB Normandie Univ, UNIROUEN, LITIS Lab QuantIF team EA4108, CHU Rouen  Rouen 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