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In this report, a leiomyoma of the thoracic esophagus was diagnosed with endobronchial ultrasound\u2010guided transbronchial mediastinal cryobiopsy (EBUS\u2010cryo). An asymptomatic 49\u2010year\u2010old woman had a 2.6\u2010cm sized submucosal tumor (SMT) of the esophagus adjacent to the trachea and left main bronchus. EBUS\u2010TBNA and EBUS\u2010guided intranodal forceps biopsy were performed, followed by EBUS\u2010cryo. The biopsy forceps could not be inserted into the tumor, but the cryoprobe was smoothly inserted. EBUS\u2010TBNA could not obtain enough spindle\u2010shaped tumor cells for immunohistochemical staining, but EBUS\u2010cryo provided sufficient specimens for diagnosing the leiomyoma. Adding EBUS\u2010cryo to EBUS\u2010TBNA has recently been reported to achieve high diagnostic yields for lymphomas, uncommon tumors, and benign diseases. EBUS\u2010cryo seems a valid diagnostic option for esophageal SMTs that are difficult to diagnose with needles and forceps.<\/jats:p>","DOI":"10.1111\/1759-7714.14650","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T03:30:01Z","timestamp":1663126201000},"page":"3068-3072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Esophageal submucosal tumor diagnosed with <scp>EBUS<\/scp>\u2010guided transbronchial mediastinal cryobiopsy: A case report"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-197X","authenticated-orcid":false,"given":"Yuki","family":"Ishiguro","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo 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