{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:01:09Z","timestamp":1791979269126,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The PACIFIC study demonstrated that durvalumab consolidation therapy significantly improved progression\u2010free survival (PFS) and overall survival (OS) in patients with unresectable stage III non\u2010small cell lung cancer (NSCLC) after concurrent chemoradiotherapy (CCRT). However, there was no clinical benefit in both PFS and OS in epidermal growth factor receptor (EGFR) mutation\u2010positive patient groups in a post hoc exploratory analysis. Moreover, the clinical effects of immune checkpoint inhibitors (ICIs) in <jats:italic>EGFR<\/jats:italic> mutation\u2010positive stage IV NSCLC were demonstrated to be poor. Personalized treatment according to the mutation status is also required in stage III NSCLC. Lazertinib, a third\u2010generation EGFR tyrosine kinase inhibitor (TKI), is newly developed and approved for use in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, open, single\u2010arm, multicenter, phase II clinical trial aims to evaluate the efficacy and safety of lazertinib as a consolidative therapy after CCRT treatment in unresectable, <jats:italic>EGFR<\/jats:italic> mutation\u2010positive NSCLC stage III patients. The primary endpoint of this study is PFS, and the secondary endpoints are OS, objective response rate (ORR), duration of response (DoR), time to death or distant metastasis (TTDM), and safety profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study may extend the indications for third\u2010generation EGFR\u2010TKIs to treat patients with stage III NSCLC. Moreover, using this drug to treat stage III NSCLC would emphasize the value of mutation analysis and personalized medicine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14663","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T07:55:58Z","timestamp":1666166158000},"page":"3431-3435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A phase <scp>II<\/scp>, multicenter study of lazertinib as consolidation therapy in patients with locally advanced, unresectable, <scp><i>EGFR<\/i><\/scp> mutation\u2010positive non\u2010small cell lung cancer (stage <scp>III<\/scp>) who have not progressed following definitive, platinum\u2010based, chemoradiation therapy (<scp>PLATINUM<\/scp> trial)"],"prefix":"10.1111","volume":"13","author":[{"given":"Juwhan","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Korea University Guro Hospital, Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-7489","authenticated-orcid":false,"given":"Jeong Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine College of Medicine, Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-4669","authenticated-orcid":false,"given":"Chang\u2010Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-1321","authenticated-orcid":false,"given":"In\u2010Jae","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School and Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Konkuk University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University Medical College  Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-313X","authenticated-orcid":false,"given":"Seung 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