{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:59Z","timestamp":1747182659616,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The correlation between COVID\u201019 and RT has not been determined to date and remains a clinical question. The aim of this study was to evaluate coronavirus disease 2019 (COVID\u201019) pneumonia before, during, and after radiation therapy (RT) regarding the radiation doses, radiation pneumonitis, and surfactant protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated patients diagnosed with COVID\u201019 before, during, or after RT for the lung between August 2020 and April 2022. In patients with breast cancer, the RT dose to the ipsilateral lung was determined. In all other patients, bilateral lung RT doses were determined. Patients diagnosed with COVID\u201019 after RT were evaluated to determine whether radiation pneumonitis had worsened compared with before RT. The serum levels of the surfactant proteins SP\u2010A and SP\u2010D were measured before, during, and after RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients included in the study comprised three men (27.3%) and eight women (72.7%). The primary cancer sites were the breast (<jats:italic>n<\/jats:italic>\u00a0=\u20097; 63.7%), lung (<jats:italic>n<\/jats:italic>\u00a0=\u00a02; 18.1%), esophagus (<jats:italic>n<\/jats:italic>\u00a0=\u00a01; 9.1%), and tongue (9.1%). COVID\u201019 was diagnosed before RT in four patients, during RT in two patients, and after RT in five patients. Six (54.5%) patients developed COVID\u201019 pneumonia. Radiation pneumonitis grade\u2009\u22652 was not identified in any patient, and radiation pneumonitis did not worsen after RT in any patient. No rapid increases or decreases in SP\u2010A and SP\u2010D levels occurred after the diagnosis of COVID\u201019 in all patients regardless of RT timing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COVID\u201019 did not appear to result in lung toxicity and surfactant protein levels did not change dramatically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14677","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:19:35Z","timestamp":1664540375000},"page":"3200-3207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coronavirus disease 2019 (<scp>COVID<\/scp>\u201019) in patients before, during, or after lung irradiation, and serum <scp>SP\u2010A<\/scp> and <scp>SP\u2010D<\/scp> levels"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-8588","authenticated-orcid":false,"given":"Naoya","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Department of Radiology Nihon University, School of Medicine  Tokyo Japan"},{"name":"Department of Radiology Nihon University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Maebayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University, School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University, School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University, School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University, School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO. 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