{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:03Z","timestamp":1747182663846,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advanced thymic carcinomas have limited treatment options. Recently, lenvatinib was approved for advanced thymic carcinoma treatment. However, the clinical benefit of lenvatinib re\u2010administration in patients with advanced thymic carcinoma who developed prior lenvatinib treatment resistance (lenvatinib rechallenge) remains unclear. Here, we present a case treated with lenvatinib rechallenge for advanced thymic carcinoma who was previously treated with lenvatinib as the second\u2010line treatment followed by multiple cytotoxic agents. Disease control rapidly deteriorated after the eighth line of treatment because of uncontrollable right pleural and pericardial effusion, which required repeated thoracic and pericardial drainage. Shortly after lenvatinib re\u2010administration, rapid pleural and pericardial effusion reduction was observed. Thereafter, the patient achieved sustained clinical response with good pleural and pericardial effusion control for approximately 7\u00a0months. Our case might suggest lenvatinib rechallenge as a treatment option for patients with advanced thymic carcinoma, especially those with poor pleural and pericardial effusion control.<\/jats:p>","DOI":"10.1111\/1759-7714.14699","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:35:25Z","timestamp":1666024525000},"page":"3408-3411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lenvatinib rechallenge in a patient with advanced thymic carcinoma: A case report"],"prefix":"10.1111","volume":"13","author":[{"given":"Yuto","family":"Terashima","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Pulmonary Medicine and Oncology Graduate School of Medicine, Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-4417","authenticated-orcid":false,"given":"Taiki","family":"Hakozaki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"},{"name":"Graduate School of Advanced Science and Engineering, Faculty of Science and Engineering Waseda University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Oncology Graduate School of Medicine, Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-5905","authenticated-orcid":false,"given":"Yukio","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology 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