{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:04:17Z","timestamp":1776830657036,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interstitial lung abnormalities (ILAs) are known to be a risk of drug\u2010induced pneumonitis. However, there are few reports on the relationship between ILAs and immune checkpoint inhibitor\u2010related interstitial lung disease (ICI\u2010ILD). We retrospectively investigated the clinical significance of ILAs in patients with non\u2010small cell lung cancer (NSCLC) receiving ICIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We defined ILAs as nondependent abnormalities affecting more than 5% of any lung zone, including ground\u2010glass or diffuse centrilobular nodularities, traction bronchiectasis, honeycombing, and nonemphysematous cysts. Early\u2010onset ICI\u2010ILD was defined as developing within 3\u00a0months after the initiation of ICI administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 264 patients with advanced NSCLC, 57 patients (21.6%) had ILAs (43 fibrotic and 14 nonfibrotic ILAs). The difference between the incidence of ICI\u2010ILD in patients with or without ILAs was not significant. Of 193 patients treated by ICI monotherapy, 18 (9.3%) developed early\u2010onset ICI\u2010ILD. Among patients receiving ICI monotherapy, the incidence of early\u2010onset ICI\u2010ILD was significantly higher in patients with than in patients without nonfibrotic ILAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of nonfibrotic ILAs is a significant risk for early\u2010onset ICI\u2010ILD in patients with NSCLC undergoing ICI monotherapy. Clinicians should be aware of ILAs, especially nonfibrotic ILAs, before administering ICIs to lung cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14718","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T04:54:50Z","timestamp":1668488090000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical significance of interstitial lung abnormalities and immune checkpoint <scp>inhibitor\u2010induced<\/scp> interstitial lung disease in patients with <scp>non\u2010small<\/scp> cell lung cancer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-5046","authenticated-orcid":false,"given":"Daiki","family":"Murata","sequence":"first","affiliation":[{"name":"Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine  Kurume 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