{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:24:05Z","timestamp":1756571045682,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigated whether radiomic features extracted from radial\u2010probe endobronchial ultrasound (radial EBUS) images can assist in decision\u2010making for subsequent clinical management in cases with indeterminate pathologic results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 494 patients who underwent radial EBUS biopsy for lung nodules between January 2017 and December 2018 were allocated to our training set. For the validation set, 229 patients with radial EBUS biopsy results from January 2019 to April 2020 were used. A multivariate logistic regression analysis was used for feature selection and prediction modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training set, 157 (67 benign and 90 malignant) of 212 patients pathologically diagnosed as indeterminate were analyzed. In the validation set, 213 patients were diagnosed as indeterminate, and 158 patients (63 benign and 95 malignant) were included in the analysis. The performance of the radiomics\u2010added model, which considered satellite nodules, linear arc, shape, patency of vessels and bronchi, echogenicity, spiculation, C\u2010reactive protein, and minimum histogram, was 0.929 for the training set and 0.877 for the validation set, whereas the performance of the model without radiomics was 0.910 and 0.891, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the next diagnostic step for indeterminate lung biopsy results remains controversial, integrating various factors, including radiomic features from radial EBUS, might facilitate decision\u2010making for subsequent clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14730","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:27:04Z","timestamp":1669026424000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nondiagnostic, radial\u2010probe endobronchial ultrasound\u2010guided biopsy for peripheral lung lesions: The added value of radiomics from ultrasound imaging for predicting malignancy"],"prefix":"10.1111","volume":"14","author":[{"given":"Jihwan","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Digital Health SAIHST, Sungkyunkwan University  Seoul South Korea"},{"name":"Hongseong\u2010gun Public Health Center  Hongseong\u2010gun South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungmin","family":"Zo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Industrial Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-4100","authenticated-orcid":false,"given":"You Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology SAIHST, Sungkyunkwan University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong Hyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical 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