{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:28:10Z","timestamp":1775737690537,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant pleural mesothelioma (MPM) is an invasive, aggressive pleural tumor with a predominantly local spread. The objective of this study was to assess thoracic ultrasound (TUS) as an imaging modality with high sensitivity for the identification of malignant pleural involvement and in order to guide pleural biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective single\u2010center study between January 2018 and June 2022, 51 consecutive patients with impassable circumferential pleural thickening underwent TUS at the Thoracic Surgery Unit of the Vanvitelli University of Naples. Pleural biopsies were performed, and then large and multiple samples were sent to the pathological anatomy for histological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all patients who underwent ultrasound examination, we chose the optimal point of entry to perform pleural biopsies and selected the areas of greater thickening without pleural effusion. No patient had any complications. No drainage tubes were placed after the pleural biopsies and no pneumothorax was present during the following days of hospitalization. The patients were discharged on the second postoperative day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With TUS the precise pleural thickening localization, local infiltration, mass extent, its nature (solid, cystic or complex) and ultrasound features can be easily defined. Furthermore, ultrasound is more economical than computed tomography and avoids the risks associated with radiation. Thoracic ultrasound is an important component of the diagnostic procedure in detecting a safe entry site for biopsies of MPMs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14735","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T06:54:47Z","timestamp":1669186487000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnosis of malignant pleural disease: Ultrasound as \u201ca detective probe\u201d"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-7201","authenticated-orcid":false,"given":"Gaetana","family":"Messina","sequence":"first","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Bove","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Natale","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Opromolla","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rainone","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Martone","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-613X","authenticated-orcid":false,"given":"Alfonso","family":"Fiorelli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vicidomini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Santini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ronchi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Massimilla","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carminia Maria","family":"Della Corte","sequence":"additional","affiliation":[{"name":"Oncology, Department of Precision Medicine Universit\u00e0 della Campania \"L. 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