{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:13:25Z","timestamp":1776334405297,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 incidence is high in patients with cancer. The fatality rate was high for the Delta variant, necessitating infection prevention by vaccination. This study evaluated the safety of a SARS\u2010CoV\u20102 vaccine in patients with advanced lung cancer receiving anticancer therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled patients receiving anticancer drugs for advanced lung cancer and planning SARS\u2010CoV\u20102 vaccination. Early side effects within 7\u2009days of vaccination were evaluated using patient\u2010reported outcome (PRO) surveys. Chi\u2010square test and multivariate logistic regression analyses were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010vaccination PROs were collected from 406 patients (252 were males). The mean age was 72\u2009years. Treatment at the time of initial vaccination included chemotherapy, immune checkpoint inhibitors (ICI), a combination of chemotherapy and ICI, targeted therapy including tyrosine kinase inhibitors, and others in 115, 93, 45, 147, and six cases, respectively. The vaccines administered were BNT162b2 and mRNA273 in 361 and three cases, respectively and unknown in 42 cases. A total of 16.1% of patients developed fever (38\u00b0C) after the second mRNA vaccination (95% confidence interval: 12.6%\u201320.1%). This rate is comparable to data previously reported in 120 patients and slightly higher than that of healthy participants of the BNT162b2 study. Patients receiving treatment with cytotoxic anticancer agents were more likely to have high fever. Multivariate analysis showed no correlation between fever frequency and patient background. No serious initial adverse events due to vaccination were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010SARS\u2010CoV\u20102 mRNA vaccination is safe; however, post\u2010vaccination fever is more common in patients undergoing lung cancer treatment than in healthy individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14737","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:30:36Z","timestamp":1669005036000},"page":"231-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of <scp>anti\u2010SARS\u2010CoV<\/scp>\u20102 messenger <scp>RNA<\/scp> vaccine in lung cancer patients undergoing anticancer chemotherapy: A multicenter, prospective, observational, <scp>patient\u2010reported<\/scp> outcome study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-2489","authenticated-orcid":false,"given":"Daijiro","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology NHO Shikoku Cancer Center  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-9029","authenticated-orcid":false,"given":"Tomoki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichiro","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kubo","sequence":"additional","affiliation":[{"name":"Center for Clinical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Chikamori","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Hospital Organization Yamaguchi\u2010Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Ochi","sequence":"additional","affiliation":[{"name":"General Internal Medicine 4, Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Kiura","sequence":"additional","affiliation":[{"name":"Department of Allergy and Respiratory Medicine Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"e069761","DOI":"10.1136\/bmj-2021-069761","article-title":"Clinical severity of, and effectiveness of mRNA vaccines against, covid\u201019 from omicron, delta, and alpha SARS\u2010CoV\u20102 variants in the United States: prospective observational study","volume":"376","author":"Lauring 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