{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:38:02Z","timestamp":1791873482784,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation and migration, and survival. Its alterations, mainly including mutations, amplifications, and overexpression are associated with poor prognosis and are one of the major drivers in non\u2013small cell lung cancer (NSCLC). Several clinical trials had been investigating on the treatments of HER2\u2010altered NSCLC, including conventional chemotherapy, programmed death 1 (PD\u20101) inhibitors, tyrosine kinase inhibitors (TKIs) and antibody\u2010drug conjugates (ADCs), however, the results were either disappointing or encouraging, but inconsistent. Trastuzumab deruxtecan (T\u2010DXd) was recently approved by the Food and Drug Administration as the first targeted agent for treating <jats:italic>HER2<\/jats:italic>\u2010mutant NSCLC. Effective screening of patients is the key to the clinical application of HER2\u2010targeted agents such as TKIs and ADCs. Various testing methods are nowadays available, including polymerase chain reaction (PCR), next\u2010generation sequencing (NGS), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), etc. Each method has its pros and cons and should be reasonably assigned to appropriate patients for diagnosis and guiding treatment decisions. To help standardize the clinical workflow, our expert group reached a consensus on the clinical management of HER2\u2010altered NSCLC, focusing on the diagnosis and treatment strategies.<\/jats:p>","DOI":"10.1111\/1759-7714.14743","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:47:11Z","timestamp":1669711631000},"page":"91-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chinese expert consensus on the diagnosis and treatment of <scp>HER2<\/scp>\u2010altered non\u2013small cell lung cancer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-1637","authenticated-orcid":false,"given":"Shirong","family":"Zhang","sequence":"first","affiliation":[{"name":"Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-4149","authenticated-orcid":false,"given":"Wenxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-6731","authenticated-orcid":false,"given":"Chunwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Basic Medicine (ICBM) Chinese Academy of Sciences  Hangzhou China"},{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-7176","authenticated-orcid":false,"given":"Yongchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of VIP Inpatient, Sun Yet\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-7775","authenticated-orcid":false,"given":"Zhengbo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-8635","authenticated-orcid":false,"given":"Wenzhao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences School of Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Cancer Jilin Cancer Hospital  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-0647","authenticated-orcid":false,"given":"Hongbing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangfeng","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-3244","authenticated-orcid":false,"given":"Liyun","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Drum Tower Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Clinical Medical School of Yangzhou University Subei People's Hospital of Jiangsu Province  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-5519","authenticated-orcid":false,"given":"Gen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Cancer Hospital and Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-5162","authenticated-orcid":false,"given":"Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oncology Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathology Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-5148","authenticated-orcid":false,"given":"Zhansheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiang","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lung Cancer and Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangzhou","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Chemotherapy, Hwamei Hospital University of Chinese Academy of Sciences  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Taizhou Hospital of Wenzhou Medical University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital) Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peking University International Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-6879","authenticated-orcid":false,"given":"Chengzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University)  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Shanxi Academy of Medical Sciences Shanxi Bethune Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Meng","sequence":"additional","affiliation":[{"name":"Cancer Center, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, the Third Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, the First Affiliated Hospital of Medicine Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, College of Medicine Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Medical Shanghai OrigiMed Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medical Shanghai OrigiMed Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Shanghai OrigiMed Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Medical Shanghai OrigiMed Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Shanghai OrigiMed Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Site","family":"Li","sequence":"additional","affiliation":[{"name":"Department of IVD Medical Marketing 3D Medicines  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of IVD Medical Marketing 3D Medicines  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Aiyi Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Medical Aiyi Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqing","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Clinical Trial Novocodex Biopharmaceutic  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Baotou Cancer Hospital  Baotou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital The Third Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Radiation Oncology Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oncology Lishui Municipal Central Hospital  Lishui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-2229","authenticated-orcid":false,"given":"Xinqing","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University)  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-4959","authenticated-orcid":false,"given":"Jing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oncology Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-2244","authenticated-orcid":false,"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Shanxi Academy of Medical Sciences Shanxi Bethune Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanxi Academy of Medical Sciences Shanxi Bethune Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5149-4632","authenticated-orcid":false,"given":"Yingying","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Interventional Oncology, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Huzhou Hospital Zhejiang University School of Medicine  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Kang","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences School of Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences School of Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences School of Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology The Third Affiliated Hospital of Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oncology Lishui Municipal Central Hospital  Lishui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, the Second Affiliated Hospital of Medical College Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingli","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Senior Department of Oncology The 5th Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-6319","authenticated-orcid":false,"given":"Donglai","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The 901 Hospital of Joint Logistics Support Force of People Liberation Army  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Zhebei Mingzhou Hospital  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital The Third Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Fourth Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Basic Medicine (ICBM) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Basic Medicine (ICBM) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhefeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Senior Department of Oncology The 5th Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lung Cancer and Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Xinqiao Hospital Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jiangsu Cancer Hospital Nanjing Medical University Affiliated Cancer Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-4131","authenticated-orcid":false,"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-643X","authenticated-orcid":false,"given":"Yuanzhi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359221082339"},{"key":"e_1_2_10_3_1","first-page":"S1283","article-title":"LBA46\u2010efficacy and safety of poziotinib in treatment\u2010na\u00efve NSCLC harboring HER2 exon 20 mutations: a multinational phase II study (ZENITH20\u20104) Ann","volume":"32","author":"Cornelissen R","year":"2021","journal-title":"Oncologia"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00297"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.9777"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112431"},{"key":"e_1_2_10_7_1","unstructured":"https:\/\/www.fda.gov\/drugs\/resources\u2010information\u2010approved\u2010drugs\/fda\u2010grants\u2010accelerated\u2010approval\u2010fam\u2010trastuzumab\u2010deruxtecan\u2010nxki\u2010her2\u2010mutant\u2010non\u2010small\u2010cell\u2010lung."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.11424"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2015.07.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36049"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00708"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0576-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/852748"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy424.063"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy424.064"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.101996"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11313"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.8546"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.657283"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2875-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.e13002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-1597"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.10.025"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/431525b"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.3780"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0912"},{"key":"e_1_2_10_27_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). Non\u2010Small Cell Lung Cancer. Version 5. 2022\u2010September 26\uff0c2022. Available atwww.nccn.org\/patients."},{"key":"e_1_2_10_28_1","unstructured":"Guidelines for non\u2010small cell lung cancer 2022.V1."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.014"},{"issue":"9","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1200\/JCO.2017.76.7293","article-title":"Molecular testing guideline for the selection of patients with lung cancer for treatment with targeted tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists\/International Association for the study of lung cancer\/association for molecular pathology clinical practice guideline update","volume":"6","author":"Kalemkerian GP","year":"2018","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091229"},{"issue":"2","key":"e_1_2_10_32_1","first-page":"2191","article-title":"Next\u2010generation sequencing\u2010based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, her\u20102 and TP53 mutations in patients with non\u2010small cell lung cancer","volume":"18","author":"Jing C","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00230"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz046"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.258632"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2683"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48212-2"},{"issue":"3","key":"e_1_2_10_38_1","first-page":"169","article-title":"Guideline for HER2 detection in breast cancer, the 2019 version","volume":"48","author":"Yang W","year":"2019","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2696"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9984"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22143"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv573"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4277-x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.07.093"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0547"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.806737"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv186"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25475"},{"key":"e_1_2_10_49_1","volume-title":"Poziotinib in non\u2010Small\u2010cell lung cancer harboring HER2 exon 20 insertion mutations after prior therapies: ZENITH20\u20102 trial","author":"Le X","year":"2021"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02245-z"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2936"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02470-6"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.1575"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.10.032"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1590"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1014"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.01.285"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:41:43Z","timestamp":1692459703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/1759-7714.14743"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14743","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]},"assertion":[{"value":"2022-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}