{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:41:21Z","timestamp":1782481281152,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The performance of uniportal VATS lobectomy (uVATS) for non\u2010small cell lung cancer (NSCLC) larger than 5\u00a0cm is uncertain due to a lack of evidence. Here, we present a retrospective, propensity\u2010score matched cohort study to evaluate the safety and effectiveness of uVATS for patients with locally advanced NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of patients with NSCLC larger than 5\u00a0cm diameter who underwent curative resection via uVATS or thoracotomy lobectomy between January 2015 and December 2020 was collected. Propensity\u2010score matching was utilized to control the observable biases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients underwent uVATS lobectomy, while 38 received thoracotomy lobectomy. No conversion to open surgery or perioperative death occurred. uVATS lobectomy achieved similar total lymph node dissection counts compared to thoracotomy and even yielded a higher amount of lymph node dissection in pTNM stage II patients. The long\u2010term overall and recurrence\u2010free survival rates were also similar between the two groups. Results from the propensity\u2010score matching generated cohort agreed with those from the full cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>uVATS lobectomy is feasible and effective for curative lobectomy for NSCLC larger than 5\u00a0cm in diameter in selected patients. Further validations from well\u2010designed prospective studies are required for uVATS lobectomy for patients with locally advanced NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14771","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T04:59:26Z","timestamp":1671857966000},"page":"489-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Uniportal <scp>VATS<\/scp> lobectomy versus thoracotomy lobectomy for <scp>NSCLC<\/scp> larger than 5\u00a0cm: A propensity score\u2010matched study"],"prefix":"10.1111","volume":"14","author":[{"given":"Jingwei","family":"Liu","sequence":"first","affiliation":[{"name":"Peking University First Hospital, Department of Thoracic Surgery Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-7867","authenticated-orcid":false,"given":"Xining","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital, Department of Thoracic Surgery Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University First Hospital, Department of Thoracic Surgery Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00173-X"},{"key":"e_1_2_8_3_1","unstructured":"YanTD BlackD BannonPG McCaughanBC.Systematic review and meta\u2010analysis of randomized and nonrandomized trials on safety and efficacy of video\u2010assisted thoracic surgery lobectomy for early\u2010stage non\u2010small\u2010cell lung cancer. 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