{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:34:04Z","timestamp":1787607244295,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lung cancer with complex epidermal growth factor receptor (EGFR) and CTNNB1 comutations is rare, and the efficacy of tyrosine kinase inhibitors (TKIs) is generally poor. Here, we encountered a lung cancer patient with complex EGFR (L858R and E709X) and CTNNB1 comutations who successfully responded to afatinib. A 78\u2010year\u2010old woman visited our hospital with a cough and bloody sputum that had worsened over the past year. She had multiple mass shadows in both lungs and nodular shadows in the bronchi. The patient was diagnosed with lung adenocarcinoma cT4N3M1c stage IVB. A genetic analysis of the primary tumor using the Oncomine Dx target test multi\u2010CDx system revealed positivity for <jats:italic>EGFR<\/jats:italic> (L858R and E709X) and CTNNB1 mutations. The expression of programmed death ligand 1 (22C3 clones) in tumor cells was negative by immunostaining. The patient was treated with afatinib as first\u2010line therapy and achieved clinical improvement and a partial response and is continuing treatment 1 year later. Case reports of lung cancer patients with EGFR\/CTNNB1 comutations are rare, and TKIs are not considered to be effective. We herein present the first case report of lung cancer with the co\u2010occurrence of uncommon and complex <jats:italic>EGFR<\/jats:italic> (L858R and E709X) and CTNNB1 mutations that was successfully treated with afatinib.<\/jats:p>","DOI":"10.1111\/1759-7714.14775","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T11:46:37Z","timestamp":1671104797000},"page":"423-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010small cell lung cancer with <scp><i>EGFR<\/i><\/scp> (<scp>L858R<\/scp> and <scp>E709X<\/scp>) and <scp>CNNB1<\/scp> mutations responded to afatinib"],"prefix":"10.1111","volume":"14","author":[{"given":"Michihiro","family":"Kunishige","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi city Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi city Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi city Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi city Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi city Kochi 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