{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:47:00Z","timestamp":1792432020885,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The combination of antiangiogenic agents with epidermal growth factor receptor inhibitors (EGFR\u2010TKIs) and chemotherapy with EGFR\u2010TKIs are the most common combination treatment options in epidermal growth factor receptor (EGFR) positive non\u2010small cell lung cancer (NSCLC). This network meta\u2010analysis was performed to evaluate the differences between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, EMBASE and the Cochrane Controlled Trials Register up to August 2022. The primary outcomes were progression\u2010free survival (PFS) and objective response rate (ORR). The secondary endpoints were overall survival (OS), disease control rate (DCR) and adverse events (AEs). The data of hazard ratio (HR) or risk ratio (RR) with their corresponding 95% confidence intervals (CIs) were extracted in the studies. A network meta\u2010analysis (NMA) was used to indirectly compare the efficacy and safety of antiangiogenic agents plus EGFR\u2010TKIs and chemotherapy plus EGFR\u2010TKIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pooled data of included studies were demonstrated that chemotherapy plus EGFR\u2010TKIs had a benefit in ORR compared to antiangiogenic agents plus EGFR\u2010TKIs in patients with <jats:italic>EGFR<\/jats:italic> mutated NSCLC (RR\u00a0=\u00a01.1, 95% CI: 1.0\u20131.2). However, there were no significant differences in PFS, OS and DCR between in the two group (PFS: HR\u00a0=\u00a01.0, 95% CI: 0.74\u20131.6; OS: HR\u00a0=\u00a00.78, 95% CI: 0.45\u20131.5; DCR: RR\u00a0=\u00a01.0, 95% CI: 0.94\u20131.1). The common treatment\u2010related AEs in the two groups were relatively manageable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the efficacy and safety, the combination of chemotherapy with EGFR\u2010TKIs is considered the best combination treatment options in advanced NSCLC with <jats:italic>EGFR<\/jats:italic> mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14783","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T07:04:31Z","timestamp":1672729471000},"page":"535-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of antiangiogenic agents or chemotherapy plus <scp>EGFR\u2010TKIs<\/scp> in advanced non\u2010small cell lung cancer: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Jiali","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidai","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erbao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Global Health, School of Public Health, Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-8617","authenticated-orcid":false,"given":"Renhua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  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