{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:19:29Z","timestamp":1789586369482,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Circular RNAs (circRNAs) play vital roles in non\u2010small cell lung cancer (NSCLC) progression. Our research analyzed the role of circ_0110498 on the cisplatin (DDP) resistance of NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cell glycolysis was analyzed by measuring glucose consumption and lactate production. Protein expression was determined by western blot analysis. The expression of circ_0110498, microRNA (miR)\u20101287\u20105p and RBBP4 was detected by RT\u2010qPCR assay. Cell counting kit\u20108, colony formation and transwell assays, together with flow cytometry were conducted to analyze cell DDP resistance, proliferation, metastasis and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circ_0110498 expression was elevated in DDP\u2010resistant NSCLC tissues and cells. Circ_0110498 silencing not only suppressed the DDP resistance of NSCLC cells by inhibiting cell growth, metastasis and glycolysis, but also enhanced the DDP sensitivity of NSCLC tumors. MiR\u20101287\u20105p was sponged by circ_0110498, and its inhibitor also reversed the effect of circ_0110498 silencing on the DDP resistance of NSCLC cells. MiR\u20101287\u20105p interacted with RBBP4, and RBBP4 overexpression partly reversed the inhibitory effect of miR\u20101287\u20105p on the DDP resistance of NSCLC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circ_0110498 facilitated DDP resistance partly through mediating the miR\u20101287\u20105p\/RBBP4 signaling in NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14787","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T06:34:20Z","timestamp":1674542060000},"page":"662-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circ_0110498 facilitates the cisplatin resistance of non\u2010small cell lung cancer by mediating the <scp>miR<\/scp>\u20101287\u20105p\/<scp>RBBP4<\/scp> axis"],"prefix":"10.1111","volume":"14","author":[{"given":"Dexun","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Geriatric Respiratory and Sleep The First Affiliated Hospital of Zhengzhou University  Zhengzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Geriatric Respiratory and Sleep The First Affiliated Hospital of Zhengzhou University  Zhengzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-4028","authenticated-orcid":false,"given":"Junguang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Respiratory and Sleep The First Affiliated Hospital of Zhengzhou University  Zhengzhou City 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