{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:44:52Z","timestamp":1783421092262,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical value of serum type I collagen cross\u2010linked amino terminal peptide (NTx) for the diagnosis of bone metastasis in lung cancer patients by evidence\u2010based medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnostic studies relevant to NTx as a serum marker for the diagnosis of bone metastasis in lung cancer patients included in the China National Knowledge Infrastructure, Wanfang, PubMed, Embase, and VIP database from the establishment of the databases to November 2022 were retrieved. Meta\u2010analysis was conducted with Stata 16.0 software to calculate the combined sensitivity (SEN), specificity (SPN), positive likelihood ratio (+LR), negative likelihood ratio (\u2212LR), diagnostic odds ratio (DOR), and its 95% confidence interval (CI). The total subject working characteristic curve (summary receiver operating characteristic (SROC) curve) was drawn, and the area under the curve was calculated to evaluate its diagnostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1742 patients with lung cancer were included in 14 articles. Meta\u2010analysis showed heterogeneity among the studies. The results of random\u2010effect model analysis demonstrated that the combined SEN, SPN, +LR, \u2212LR, and DOR were 0.76 (95% CI 0.66\u20130.83), 0.80 (95% CI 0.74\u20130.85), 3.80 (95% CI 2.90\u20134.80), 0.30 (95% CI 0.22\u20130.42), and 12 (95% CI 8\u201319), respectively, and the area under SROC was 0.85.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum NTx has a high clinical value in the diagnosis of bone metastasis in lung cancer patients and can be used as an effective complementary means for imaging diagnosis of bone metastasis in lung cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14808","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T04:34:46Z","timestamp":1675139686000},"page":"787-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum cross\u2010linked N\u2010telopeptide of type I collagen as a potential diagnostic marker for bone metastasis in lung cancer: An updated meta\u2010analysis"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-7173","authenticated-orcid":false,"given":"Haiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Deaprtment of Respiratory Hangzhou Third People's Hospital  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zhejiang Hospital  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[{"name":"Deaprtment of Respiratory Hangzhou Third People's Hospital  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baona","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gerontology Hangzhou Third People's Hospital  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18670"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515600187"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2018.1463566"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01109-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.3.388"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_6_9_1","first-page":"478","article-title":"Combined examination of serum cross\u00b7\u2010linked N\u2010telopeptides of type I collagen and bone sialoprotein in detection of bone metastasis of breast cancer and lung cancer","volume":"05","author":"Wang W","year":"2008","journal-title":"Chin J Cancer Biotherap"},{"issue":"6","key":"e_1_2_6_10_1","first-page":"534","article-title":"Relationships between the levels of serum NTx, ICTP, BAP and bone metastasis in patients with lung cancer","volume":"16","author":"Zhang SQ","year":"2011","journal-title":"Chin Clin Oncol"},{"issue":"11","key":"e_1_2_6_11_1","first-page":"3879","article-title":"Serum N\u2010telopeptide of type I collagen and bone alkaline phosphatase and their relationship in patients with non\u2010small cell lung carcinoma and bone metastases. 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