{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:58Z","timestamp":1759541338900,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pre\u2010invasive squamous lesions of the central airways can progress into invasive lung cancers. Identifying these high\u2010risk patients could enable detection of invasive lung cancers at an early stage. In this study, we investigated the value of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) positron emission tomography (PET) scans in predicting progression in patients with pre\u2010invasive squamous endobronchial lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, patients with pre\u2010invasive endobronchial lesions, who underwent an <jats:sup>18<\/jats:sup>F\u2010FDG PET scan at the VU University Medical Center Amsterdam, between January 2000 and December 2016, were included. Autofluorescence bronchoscopy (AFB) was used for tissue sampling and was repeated every 3\u2009months. The minimum and median follow\u2010up was 3 and 46.5\u00a0months. Study endpoints were the occurrence of biopsy proven invasive carcinoma, time\u2010to\u2010progression and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total number of 40 of 225 patients met the inclusion criteria of which 17 (42.5%) patients had a positive baseline <jats:sup>18<\/jats:sup>F\u2010FDG PET scan. A total of 13 of 17 (76.5%) developed invasive lung carcinoma during follow\u2010up, with a median time to progression of 5.0\u00a0months (range, 3.0\u201325.0). In 23 (57.5%) patients with a negative <jats:sup>18<\/jats:sup>F\u2010FDG PET scan at baseline, 6 (26%) developed lung cancer, with a median time to progression of 34.0\u00a0months (range, 14.0\u201342.0\u00a0months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002). With a median OS of 56.0\u00a0months (range, 9.0\u201360.0\u2009months) versus 49.0\u00a0months (range, 6.0\u201360.0\u00a0months) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.876) for the\u00a0<jats:sup>18<\/jats:sup>F\u2010FDG PET positive and negative groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with pre\u2010invasive endobronchial squamous lesions and a positive baseline <jats:sup>18<\/jats:sup>F\u2010FDG PET scan were at high\u2010risk for developing lung carcinoma, highlighting that this patient group requires early radical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14815","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:29:43Z","timestamp":1676744983000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Focal <scp><sup>18<\/sup>F\u2010FDG<\/scp> uptake predicts progression of pre\u2010invasive squamous bronchial lesions to invasive cancers"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-4155","authenticated-orcid":false,"given":"Illaa","family":"Smesseim","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases Amsterdam University Medical Center, Location Free University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"van Boerdonk","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Dickhoff","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Heineman","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max R.","family":"Dahele","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Radonic","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idris","family":"Bahce","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Amsterdam University Medical Center, Location Free University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone P.","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile F. 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