{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:14:58Z","timestamp":1777896898579,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thoracic SMARCA4\u2010deficient undifferentiated tumors (SMARCA4\u2010UT) have a poor prognosis and are often diagnosed at an inoperable advanced stage. Herein, we report a case of SMARCA4\u2010UT diagnosed by endobronchial ultrasound\u2010guided transbronchial cryobiopsy (EBUS\u2010cryo). The patient was a 42\u2010year\u2010old man with a history of smoking. Chest computed tomography revealed a right upper lobe nodule and an enlarged #11s lymph node. Core tissues could not be obtained by EBUS\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) for diagnosis and mediastinal staging; hence, EBUS\u2010guided intranodal forceps biopsy (EBUS\u2010IFB) was performed. However, a detailed diagnosis beyond poorly differentiated carcinoma could not be obtained. Subsequent EBUS\u2010cryo provided sufficient specimens for immunohistochemical and molecular evaluation and SMARCA4\u2010UT was definitively diagnosed. Thus, EBUS\u2010cryo could be of additional diagnostic value for uncommon tumors, such as SMARCA4\u2010UT, conjointly with EBUS\u2010IFB as well as EBUS\u2010TBNA.<\/jats:p>","DOI":"10.1111\/1759-7714.14830","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T03:59:05Z","timestamp":1677297545000},"page":"953-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Thoracic <scp>SMARCA4<\/scp>\u2010deficient undifferentiated tumor diagnosed by transbronchial mediastinal cryobiopsy: A case report"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-4823","authenticated-orcid":false,"given":"Chihiro","family":"Takemura","sequence":"first","affiliation":[{"name":"National Cancer Center Japan, Respiratory Endoscopy Division  Chuo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-5306","authenticated-orcid":false,"given":"Tatsuya","family":"Imabayashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Chuo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Furuse","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Japan  Chuo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Uchimura","sequence":"additional","affiliation":[{"name":"Respiratory Endoscopy Division National Cancer Center Japan  Chuo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Cancer Center Japan  Chuo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Chuo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun\u2010ichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery National Cancer Center Hospital  Chuo\u2010ku Tokyo 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diseases: a multicentre, open\u2010label, randomised trial","volume":"22","author":"Fan Y","year":"2022","journal-title":"Lancet Respir Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01814-x"},{"key":"e_1_2_7_12_1","first-page":"1","article-title":"Feasibility of modified endobronchial ultrasound\u2010guided intranodal forceps biopsy: a retrospective analysis","volume":"102","author":"Konno\u2010Yamamoto 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