{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T16:09:55Z","timestamp":1769357395545,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972175 & 82203296"],"award-info":[{"award-number":["81972175 & 82203296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Segmentectomy has been recommended for ground glass opacity (GGO)\u2010dominant small\u2010sized non\u2013small cell lung cancer (NSCLC) or those with GGO component. Pure solid NSCLC is a special sub\u2010type and has an inferior prognosis. Whether segmentectomy could achieve comparable long\u2010term outcomes with lobectomy for pure solid small\u2010sized NSCLC remained controversial. This study aimed to compare the prognosis of segmentectomy and lobectomy for pure solid NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NSCLC patients with a pure solid nodule (\u22642\u00a0cm) who received segmentectomy or lobectomy between January 2010 and June 2019 were retrospectively screened. Log\u2010rank test, univariable, and multivariable Cox regression analyses were used for prognostic comparison. Further, the propensity score matching analysis was adopted to yield a matched cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening, 344 pure solid NSCLC patients with a median follow\u2010up time of 56\u2009months were reserved. Among them, 98 patients underwent segmentectomy and the other 246 subjects received lobectomy. The lobectomy group had a larger tumor size, a higher rate of lymph node metastasis than the segmentectomy arm. Generally, patients with segmentectomy had a better disease\u2010free survival (DFS) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) and overall survival (OS) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) than those with lobectomy. However, the multivariable Cox regression analysis indicated that no significant survival difference existed between segmentectomy and lobectomy after adjusting the potential confounding factors (DFS: hazard ratio [HR],\u00a00.72; 95% confidence interval [CI], 0.30\u20131.77, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.476; OS: HR,\u00a00.36; 95% CI, 0.08\u20131.59, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.178). Consistently, in the propensity score matched cohort, segmentectomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a074) yielded similar DFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.960) and OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.320) with lobectomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a074).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Segmentectomy could achieve comparable oncological outcomes with lobectomy for pure solid small\u2010sized NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14840","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T03:00:00Z","timestamp":1678244400000},"page":"1021-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Segmentectomy versus lobectomy for small\u2010sized pure solid non\u2013small cell lung cancer"],"prefix":"10.1111","volume":"14","author":[{"given":"Zhihua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-9046","authenticated-orcid":false,"given":"Weibing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-4273","authenticated-orcid":false,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.06.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa231"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02333-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.01.107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezac166","article-title":"The prognostic impact of the ground\u2010glass opacity component in nearly pure\u2010solid stage IA non\u2010small\u2010cell lung cancer","volume":"62","author":"Kamigaichi A","year":"2022","journal-title":"Eur J Cardiothorac 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