{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:40:52Z","timestamp":1765438852253,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dabrafenib plus trametinib is the standard treatment for <jats:italic>BRAF V600E<\/jats:italic>\u2010mutated non\u2010small cell lung cancer. No treatment\u2010related cerebral infarction (CI) has been reported in previous clinical trials. Here, we described a 61\u2010year\u2010old Japanese man with <jats:italic>BRAF V600E<\/jats:italic>\u2010mutated lung adenocarcinoma treated with dabrafenib plus trametinib as a third\u2010line treatment. On the 10th day of dabrafenib plus trametinib treatment, the patient developed fever and was urgently hospitalized on the 18th day owing to impaired consciousness. The patient had disseminated intravascular coagulation because of infection, was treated with thrombomodulin and ceftriaxone, and subsequently improved. On the 44th day, dabrafenib plus trametinib was resumed with a one\u2010step dose reduction. Three hours after the first oral administration, the patient developed chills, fever, and hypotension. He received intravenous fluids. On the 64th day, 20\u2009mg prednisolone was administered from the previous day, and dabrafenib plus trametinib was resumed with a further one\u2010step reduction in dose. Five hours after the first oral administration, the patient developed fever, hypotension, paralysis of the right upper and lower limbs, and\u00a0dysarthria\u00a0appeared. Head magnetic resonance imaging revealed multiple cerebral infarcts. Hemoconcentration because of intravascular dehydration may have caused CI. In conclusion, CI should be taken into consideration during treatment with dabrafenib plus trametinib.<\/jats:p>","DOI":"10.1111\/1759-7714.14852","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:44:31Z","timestamp":1679283871000},"page":"1201-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral infarction after treatment with dabrafenib plus trametinib for <scp>BRAF\u2010V600E<\/scp>\u2010positive non\u2013small cell lung cancer: A case report"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-3683","authenticated-orcid":false,"given":"Yoshihiko","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai 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