{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:47:09Z","timestamp":1772052429535,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the clinical significance of preoperative systemic immune\u2010inflammation index (SII) in patients with thymoma who underwent radical resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved 425 patients with thymoma who underwent radical resection at the First Affiliated Hospital of Nanjing Medical University between September 1, 2008 and December 30, 2019. Data regarding routine preoperative blood tests and clinical features were collected to calculate and analyze the SII, platelet\u2010to\u2010lymphocyte ratio (PLR), and neutrophil\u2010to\u2010lymphocyte ratio (NLR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis indicated that age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021), tumor size (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), extended resection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), Masaoka\u2010Koga stage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), PLR (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012), NLR (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041), and SII (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) were related to patient prognosis. A higher SII (&gt;345.83) was a significant independent prognostic factor in this cohort (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, HR\u00a0=\u00a05.756, 95% CI: 2.144\u201315.457). Multivariate analysis showed that a high PLR was significantly associated with overall survival (OS) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008, HR\u00a0=\u00a03.29, 95% CI: 1.371\u20137.896), while a high NLR was a significant independent prognostic factor for shorter OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024, HR\u00a0=\u00a02.654, 95% CI: 1.138\u20136.19). SII had an area under the curve (AUC) of 70.6% (AUC\u00a0=\u00a00.706) exceeding the predictive value for PLR (AUC\u00a0=\u00a00.678) and NLR (AUC\u00a0=\u00a00.654).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative SII can predict the prognosis of thymoma patients who have undergone radical resection but further multicenter prospective studies are needed to investigate the role of SII in thymoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14854","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T09:16:27Z","timestamp":1679562987000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preoperative systemic immune\u2010inflammation index for predicting the prognosis of thymoma with radical 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