{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:48:20Z","timestamp":1759495700665,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymic neuroendocrine tumors associated with multiple endocrine neoplasia are only defined as carcinoid and are not associated with large\u2010cell neuroendocrine carcinoma (LCNEC). We report the case of a multiple endocrine neoplasia type 1 patient with atypical carcinoid tumors with elevated mitotic counts (AC\u2010h), an intermediate condition between carcinoid and LCNEC. A 27\u2010year\u2010old man underwent surgery for an anterior mediastinal mass and was diagnosed with thymic LCNEC. Fifteen years later, a mass appeared at the same site, which was determined to be a postoperative recurrence based on the pathological results of a needle biopsy and the clinical course. The patient's disease remained stable for 10\u2009months on anti\u2010programmed death\u2010ligand 1 antibody and platinum\u2010containing chemotherapy. The needle biopsy specimen was submitted for next\u2010generation sequencing, which revealed a <jats:italic>MEN1<\/jats:italic> gene mutation, and after further examination, a diagnosis of multiple endocrine neoplasia type 1 was made. A re\u2010examination of the surgical specimen from 15\u2009years prior showed that it corresponded to AC\u2010h. Although thymic AC\u2010h is classified as thymic LCNEC according to the current definition, our data suggests that a search for multiple endocrine neoplasia is warranted in such patients.<\/jats:p>","DOI":"10.1111\/1759-7714.14863","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T01:33:51Z","timestamp":1679362431000},"page":"1311-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thymic atypical carcinoid tumors with elevated mitotic counts in a patient with multiple endocrine neoplasia: A case report"],"prefix":"10.1111","volume":"14","author":[{"given":"Shuntaro","family":"Hiro","sequence":"first","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama 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