{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:39Z","timestamp":1792644819329,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate whether whole\u2010brain radiotherapy (WBRT) decreases lymphocyte counts and evaluate the impact of treatment\u2010related lymphopenia on survival in patients with brain metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records from 60 small\u2010cell lung cancer patients treated with WBRT from January 2010 to December 2018 were included in the study. Total lymphocyte count (TLC) was obtained pre and post treatment (within 1\u2009month). We performed linear and logistic regression analyses to identify predictors of lymphopenia. The association between lymphopenia and survival was analyzed using Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients (65%) developed treatment\u2010related lymphopenia. The median TLC decrease was \u2212374\u2009cells\/\u03bcL (interquartile range \u221250 to \u2212722, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Baseline lymphocyte count was a significant predictor of TLC difference and percentage change in TLC. Logistic regression analysis found male sex (odds ratio [OR] 0.11, 95% confidence interval [CI] 0.00\u20130.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.033) and higher baseline lymphocyte count (OR 0.91, 95% CI 0.82\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) were associated with a lower risk of developing \u2265grade 2 treatment\u2010related lymphopenia. Cox regression analysis showed that age at brain metastasis (hazard ratio [HR] 1.03, 95% CI 1.01\u20131.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.013), \u2265grade 2 treatment\u2010related lymphopenia, and percentage change in TLC (per 10%, HR 0.94, 95% CI 0.89\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.032) were prognostic factors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WBRT decreases TLC and the magnitude of treatment\u2010related lymphopenia is an independent predictor of survival in small\u2010cell lung cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14868","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T11:35:00Z","timestamp":1680176100000},"page":"1268-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lymphocytopenia and survival after whole\u2010brain radiotherapy in patients with small\u2010cell lung cancer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-9904","authenticated-orcid":false,"given":"Yu\u2010Jung","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Taipei Veterans General Hospital  No.201, Sec. 2, Shipai Rd., Beitou District Taipei City 11217 Taiwan, ROC"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  No. 155, Sec. 2, Linong St. Beitou Dist Taipei City 112304 Taiwan, ROC"},{"name":"Institute of Clinical Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Mei","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Taipei Veterans General Hospital  No.201, Sec. 2, Shipai Rd., Beitou District Taipei City 11217 Taiwan, ROC"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  No. 155, Sec. 2, Linong St. Beitou Dist Taipei City 112304 Taiwan, ROC"},{"name":"Institute of Clinical Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Hung","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Taipei Veterans General Hospital  No.201, Sec. 2, Shipai Rd., Beitou District Taipei City 11217 Taiwan, ROC"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  No. 155, Sec. 2, Linong St. Beitou Dist Taipei City 112304 Taiwan, ROC"},{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Taipei Veterans General Hospital  No.201, Sec. 2, Shipai Rd., Beitou District Taipei City 11217 Taiwan, ROC"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  No. 155, Sec. 2, Linong St. Beitou Dist Taipei City 112304 Taiwan, ROC"},{"name":"Department of Medical Imaging and Radiological Technology Yuanpei University of Medical Technology  No. 306, Yuanpei Street Hsinchu 30015 Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Taipei Veterans General Hospital  No.201, Sec. 2, Shipai Rd., Beitou District Taipei City 11217 Taiwan, ROC"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  No. 155, Sec. 2, Linong St. Beitou Dist Taipei City 112304 Taiwan, ROC"},{"name":"Institute of Public Health National Yang Ming Chiao Tung University  Taipei Taiwan, 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